ceftriaxone [Ligand Id: 5326] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL161 (Ceftriaxon, Ceftriaxone) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) by circular dichroism analysis | B | 6.28 | pKd | 530 | nM | Kd | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| D-amino-acid oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5485] [UniProtKB: P14920] | ||||||||
| ChEMBL | Inhibition of DAAO (unknown origin) | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2015) 58: 7258-7272 [PMID:26309148] |
| Organic anion transporter 4/Solute carrier family 22 member 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073677] [GtoPdb: 1030] [UniProtKB: Q9NSA0] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells | F | 5.62 | pKi | 2380 | nM | Ki | Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604] |
| Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | F | 6.64 | pKi | 230 | nM | Ki | Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604] |
| Organic anion transporter 3/Solute carrier family 22 member 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641348] [GtoPdb: 1027] [UniProtKB: Q8TCC7] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | F | 5.36 | pKi | 4390 | nM | Ki | Eur J Pharmacol (2002) 438: 137-142 [PMID:11909604] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
