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tigemonam   Click here for help

GtoPdb Ligand ID: 10867

Synonyms: SQ-30213 | SQ-30836 (tigemonam dicholate) | SQ30213 | SQ30836 (tigemonam dicholate)
Compound class: Synthetic organic
Comment: Tigemonam is a monobactam antibacterial [1-2]. It has Gram-positive activity, and is stable against β-lactamases, but has no activity against Psedomonas. SQ-30836 (tigemonam dicholate) is an orally absorbed salt of tigemonam [3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 247.43
Molecular weight 437.03
XLogP -2.08
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC(=O)CO/N=C(/c1csc(n1)N)\C(=O)N[C@@H]1C(=O)N(C1(C)C)OS(=O)(=O)O
Isomeric SMILES OC(=O)CO/N=C(/c1csc(n1)N)\C(=O)N[C@@H]1C(=O)N(C1(C)C)OS(=O)(=O)O
InChI InChI=1S/C12H15N5O9S2/c1-12(2)8(10(21)17(12)26-28(22,23)24)15-9(20)7(16-25-3-6(18)19)5-4-27-11(13)14-5/h4,8H,3H2,1-2H3,(H2,13,14)(H,15,20)(H,18,19)(H,22,23,24)/b16-7-/t8-/m1/s1
InChI Key VAMSVIZLXJOLHZ-QWFSEIHXSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-sulfooxyazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acid
International Nonproprietary Names Click here for help
INN number INN
6100 tigemonam
Synonyms Click here for help
SQ-30213 | SQ-30836 (tigemonam dicholate) | SQ30213 | SQ30836 (tigemonam dicholate)
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Tigemonam
Other databases
DrugCentral Ligand 3842
GtoPdb PubChem SID 405560308
PubChem CID 5486705
Search Google for chemical match using the InChIKey VAMSVIZLXJOLHZ-QWFSEIHXSA-N
Search Google for chemicals with the same backbone VAMSVIZLXJOLHZ
Search PubMed clinical trials tigemonam
Search PubMed titles tigemonam
Search PubMed titles/abstracts tigemonam
UniChem Compound Search for chemical match using the InChIKey VAMSVIZLXJOLHZ-QWFSEIHXSA-N
UniChem Connectivity Search for chemical match using the InChIKey VAMSVIZLXJOLHZ-QWFSEIHXSA-N