tubercidin [Ligand Id: 4755] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL267099 (Tubercidin)
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand. B 4 pKi >100000 nM Ki J Med Chem (1995) 38: 1174-1188 [PMID:7707320]
Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263]
ChEMBL Inhibition of recombinant human adenosine kinase B 5 pIC50 10000 nM IC50 J Med Chem (2000) 43: 2883-2893 [PMID:10956196]
heat shock protein family A (Hsp70) member 8/Heat shock cognate 71 kDa protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1275223] [GtoPdb: 2543] [UniProtKB: P11142]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 4.55 pKd 28183.83 nM Kd J Med Chem (2016) 59: 4625-4636 [PMID:27119979]
ChEMBL Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis B 4.55 pKd 28000 nM Kd J Med Chem (2016) 59: 4625-4636 [PMID:27119979]
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-induced cytopathic effect after 5 days by MTS assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by measuring reduction in virus-yield B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by methylene blue staining based by Plaque reduction assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
ChEMBL Inhibition of RNA-dependent RNA polymerase in Zika virus MR766 infected in African green monkey Vero cells assessed as antiviral activity by Alexa Fluor 488/DAPI staining based assay B 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 470-489 [PMID:31549836]
Programmed cell death protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781868] [UniProtKB: Q53EL6]
ChEMBL Stabilization of Pdcd4 expressed in human HEK293 cells assessed as inhibition of TPA-induced degradation by luciferase reporter assay B 6.06 pIC50 880 nM IC50 J Nat Prod (2011) 74: 1990-1995 [PMID:21870828]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]