ChEMBL ligand: CHEMBL529 (Anhydrous azithromycin, Aruzilina, Azasite, Aziromycin, Azithrocin, Azithromycin, Azithromycin anhydrous, Azithromycin (as dihydrate), Azithromycin dihydrate, Azithromycin hydrate, Azithromycin, unspecified, Azithromycin, unspecified form, Aziwin, Azyter, Clamelle, CP 62993, CP-62993, CP-62,993, Durasite, Hemomycin, Macrozit, NSC-758625, Sumamed, Sunamed, Trozocina, Xithrone, XZ 405, XZ 450, XZ-450, Zithromac, Zithromax, ZMax, Zythromax)
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
motilin receptor in Human [GtoPdb: 297] [UniProtKB: O43193] There should be some charts here, you may need to enable JavaScript!
TAS2R4 in Human [GtoPdb: 661] [UniProtKB: Q9NYW5] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum GCO3 by [3H]hypoxanthine uptake	F	4.65	pIC50	22585	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	4.8	pIC50	15742	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7A infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique	F	4.94	pIC50	11513	nM	IC50	Eur J Med Chem (2012) 49: 365-378 [PMID:22321992]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7A infected in type A rhesus-positive human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	4.94	pIC50	11513	nM	IC50	J Med Chem (2012) 55: 3216-3227 [PMID:22380766]
ChEMBL	Antiplasmodial activity after 48 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity	F	5.04	pIC50	9040	nM	IC50	Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs	F	5.06	pIC50	8700	nM	IC50	J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL	Antimalarial activity as 2nd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs by flow cytometry	F	5.06	pIC50	8670	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR 3TC after 48 hrs	F	5.19	pIC50	6500	nM	IC50	J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL	Antiplasmodial activity after 72 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity	F	5.34	pIC50	4570	nM	IC50	Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275]
ChEMBL	Antimalarial activity against Plasmodium falciparum isolates assessed as parasite growth inhibition after 72 hrs by ELISA based histidine-rich protein 2 in vitro drug susceptibility assay	F	5.37	pIC50	4314.35	nM	IC50	Antimicrob Agents Chemother (2009) 53: 4040-4042 [PMID:19596882]
ChEMBL	Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	5.4	pIC50	3971.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 48 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	5.46	pIC50	3464	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique	F	5.57	pIC50	2680	nM	IC50	Eur J Med Chem (2012) 49: 365-378 [PMID:22321992]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in type A rhesus-positive human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by scintillation counting	F	5.57	pIC50	2680	nM	IC50	J Med Chem (2012) 55: 3216-3227 [PMID:22380766]
ChEMBL	Antimalarial activity against mefloquine-resistant Plasmodium falciparum TM91C235 assessed as [3H]hypoxanthine incorporation after 48 hrs	F	5.58	pIC50	2654	nM	IC50	J Med Chem (2012) 55: 1389-1401 [PMID:22148880]
ChEMBL	Antimalarial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum W2 after 48 hrs by [3H]hypoxanthine incorporation assay	F	5.64	pIC50	2294	nM	IC50	J Med Chem (2011) 54: 3595-3605 [PMID:21476508]
ChEMBL	Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	5.65	pIC50	2241	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 after 48 hrs by [3H]hypoxanthine incorporation assay	F	5.68	pIC50	2112	nM	IC50	J Med Chem (2011) 54: 3595-3605 [PMID:21476508]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	5.69	pIC50	2065	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antimalarial activity after 96 hrs against azithromycin-resistant Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	5.71	pIC50	1938.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity as 2nd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry	F	5.84	pIC50	1460	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by [3H]hypoxanthine incorporation assay	F	5.98	pIC50	1039	nM	IC50	J Med Chem (2011) 54: 3595-3605 [PMID:21476508]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting	F	5.99	pIC50	1015	nM	IC50	Bioorg Med Chem (2011) 19: 1692-1701 [PMID:21316974]
ChEMBL	Antiplasmodial activity after 96 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity	F	6.03	pIC50	940	nM	IC50	Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275]
ChEMBL	Antiplasmodial activity after 120 hrs against Plasmodium falciparum 3D7 as Malstat LDH activity	F	6.39	pIC50	410	nM	IC50	Antimicrob Agents Chemother (2008) 52: 774-777 [PMID:18056275]
ChEMBL	Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake	F	6.64	pIC50	228.1	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum 3BA6 CDY mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	6.71	pIC50	194.2	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum 3BA6 by [3H]hypoxanthine uptake	F	6.74	pIC50	180.3	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum 3BA6 SND mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	6.8	pIC50	157.9	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3BA6 SDD with CRT and MDR1 mutation after 96 hrs in [3H]hypoxanthine uptake	F	6.81	pIC50	154.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum 7G8 C1 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	6.85	pIC50	141.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 T76K1 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	6.91	pIC50	121.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum 7G8 T76K1 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	6.94	pIC50	114.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 by [3H]hypoxanthine uptake	F	6.99	pIC50	103.4	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum Dd2 C1 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.02	pIC50	95.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 C6 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.12	pIC50	76.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 CDY mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.15	pIC50	70.2	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 C4 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.18	pIC50	66.7	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 SDD mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.2	pIC50	63.3	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 after 96 hrs	F	7.28	pIC50	53	nM	IC50	J Med Chem (2016) 59: 5587-5603 [PMID:26791529]
ChEMBL	Antimalarial activity as 3rd generation ring-stage chloroquine-sensitive Plasmodium falciparum 3D7 after 48 hrs dose then 48 hrs drug-free	F	7.28	pIC50	52.7	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
ChEMBL	Antimalarial activity after 96hrs against Plasmodium falciparum GCO3 C2 mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.32	pIC50	48	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 SND mutant CRT/MDR1 by [3H]hypoxanthine uptake	F	7.32	pIC50	47.8	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity after 96 hrs against Plasmodium falciparum GCO3 by [3H]hypoxanthine uptake	F	7.36	pIC50	43.3	nM	IC50	J Biol Chem (2007) 282: 2494-2504 [PMID:17110371]
ChEMBL	Antimalarial activity as 3rd generation ring-stage chloroquine-resistant Plasmodium falciparum W2 after 48 hrs dose then 48 hrs drug-free	F	7.51	pIC50	31	nM	IC50	Antimicrob Agents Chemother (2007) 51: 3485-3490 [PMID:17698630]
motilin receptor in Human [GtoPdb: 297] [UniProtKB: O43193]
GtoPdb	-	-	5.5	pEC50	-	-	-	Br J Pharmacol (2013) 168: 1859-67 [PMID:23190027]
TAS2R4 in Human [GtoPdb: 661] [UniProtKB: Q9NYW5]
GtoPdb	-	-	4.13	pEC50	74450	nM	EC50	FASEB J (2019) 33: 501-517 [PMID:30011231]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]