gilteritinib [Ligand Id: 8708] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3301622 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fms related receptor tyrosine kinase 3 in Human [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| GtoPdb | - | - | 9.52 | pIC50 | ~0.3 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| GtoPdb | - | - | 8.96 | pIC50 | ~1.1 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| GtoPdb | - | - | 9.1 | pIC50 | ~0.8 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| GtoPdb | - | - | 8.52 | pIC50 | ~3 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| leukocyte receptor tyrosine kinase in Human [GtoPdb: 1838] [UniProtKB: P29376] | ||||||||
| GtoPdb | - | - | 9.7 | pIC50 | ~0.2 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| ALK receptor tyrosine kinase in Human [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| GtoPdb | - | - | 9.3 | pIC50 | ~0.5 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| c-ros oncogene 1, receptor tyrosine kinase in Human [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| GtoPdb | - | - | 8.82 | pIC50 | ~1.5 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
| ret proto-oncogene in Human [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| GtoPdb | - | - | 8.77 | pIC50 | ~1.7 | nM | IC50 | Blood (2017) 129: 257-260 [PMID:27908881] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
