bafetinib [Ligand Id: 7906] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL206834 (Bafetinib, INNO-406, NS-187, CNS-9)
  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
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  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of human Abl kinase expressed in Sf9 cells B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 8.24 pIC50 5.8 nM IC50 Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680];
Blood (2005) 106: 3948-54 [PMID:16105974]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of human Lyn kinase expressed in Sf9 cells B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]