bafetinib [Ligand Id: 7906] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL206834 (Bafetinib, INNO-406, NS-187, CNS-9)
  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
  • This target only has 0 pki data point
  • 0
1 CHEMBL206834_lig_chart_1 Tyrosine-protein kinase ABL Human
There should be some charts here, you may need to enable JavaScript!
  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
  • This target only has 0 pki data point
  • 0
2 CHEMBL206834_lig_chart_2 Tyrosine-protein kinase Lyn Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of human Abl kinase expressed in Sf9 cells B 7.59 pIC50 26 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 8.24 pIC50 5.8 nM IC50 Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680];
Blood (2005) 106: 3948-54 [PMID:16105974]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of human Lyn kinase expressed in Sf9 cells B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680]
GtoPdb - - 7.96 pIC50 11 nM IC50 Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]