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ChEMBL ligand: CHEMBL206834 (Bafetinib, INNO-406, NS-187, CNS-9) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
ChEMBL | Inhibition of human Abl kinase expressed in Sf9 cells | B | 7.59 | pIC50 | 26 | nM | IC50 | Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680] |
GtoPdb | - | - | 8.24 | pIC50 | 5.8 | nM | IC50 |
Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680]; Blood (2005) 106: 3948-54 [PMID:16105974] |
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
ChEMBL | Inhibition of human Lyn kinase expressed in Sf9 cells | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg. Med. Chem. Lett. (2007) 17: 2712-2717 [PMID:17376680] |
GtoPdb | - | - | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2712-7 [PMID:17376680] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]