atezolizumab   Click here for help

GtoPdb Ligand ID: 7990

Synonyms: MPDL3280A | Tecentriq®
Approved drug Immunopharmacology Ligand
atezolizumab is an approved drug (FDA (2016), EMA (2017))
Compound class: Antibody
Comment: Atezolizumab (MPDL3280A) is a monoclonal antibody directed against programmed death-1 ligand-1 (PD-L1, aka CD274), an important immunopharmacological drug discovery target in immuno-oncology.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence analysis using the light chain variable region of atezolizumab provides a 100% match to sequence 21 from patent US8217149. An X-ray crystal structure of the PD-L1/atezolizumab complex has been submitted to the RCSB PDB (accession 5X8L) [3].
Classification Click here for help
Compound class Antibody
Approved drug? Yes (FDA (2016), EMA (2017))
International Nonproprietary Names Click here for help
INN number INN
9814 atezolizumab
Synonyms Click here for help
MPDL3280A | Tecentriq®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 526
Other databases
GtoPdb PubChem SID 249565671
Search PubMed clinical trials atezolizumab
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Wikipedia Atezolizumab