vadastuximab talirine   Click here for help

GtoPdb Ligand ID: 9434

Synonyms: SGN-CD33A
Immunopharmacology Ligand
Compound class: Antibody
Comment: Vadastuximab talirine (SGN-CD33A; Seattle Genetics) is an humanized anti-CD33 antibody-drug conjugate (ADC) which delivers a toxic payload to CD33 +ve cells [1]. Talirine is a pyrrolobenzodiazepine (PBD) dimer (PubChem CID 45257190), which is a DNA crosslinking agent, causing DNA damage and ultimately apoptosis of targeted cells. Talirine is conjugated to engineered Cys residues in the antibody via a cathepsine B cleavable linker.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Classification Click here for help
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
International Nonproprietary Names Click here for help
INN number INN
9983 vadastuximab talirine
Synonyms Click here for help
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 552
Other databases
GtoPdb PubChem SID 329968375
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