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tegoprubart   Click here for help

GtoPdb Ligand ID: 14508

Synonyms: AT-1501 | AT1501
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tegoprubart (AT-1501) is a monoclonal antibody that targets human CD40 ligand (CD40LG; CD154). Signalling via the CD40-CD40L costimulatory pathway is a recognized mechanism that can drive transplant (graft) rejection and inhibition/blockade of this pathway is considered as a potential therapeutic approach to achieve transplant tolerance and graft survival [3-5]. Tegoprubart is modified to prevent FcγRII receptor-mediated platelet activation and reduce the risk of drug-induced thromboembolic events.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
12545 tegoprubart
Synonyms Click here for help
AT-1501 | AT1501
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1433
Other databases
Search PubMed clinical trials tegoprubart
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