Oleclumab (MEDI9447) is a monoclonal antibody targeting the ecto-5'-nucleotidase (CD73), which is being investigated for oncology use [1-2
]. Functional studies show that MEDI9447 is a high affinity antagonistic mAb, showing non-competitive inhibition of CD73 hydrolysis of AMP[1
]. Two modes of action are suggested: prevention of steric conformational change required for catalytic active state, and inter-CD73 dimer cross-linking.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.