moxetumomab pasudotox [Ligand Id: 7675] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1743043 (CAT-8015, HA-22, HA22, Lumoxiti, Moxetumomab pasudotox, Moxetumomab pasudotox tdfk, Moxetumomab pasudotox-tdfk) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273] | ||||||||
| GtoPdb | - | - | 8.22 | pKd | 6 | nM | Kd |
J Clin Oncol (2012) 30: 1822-8 [PMID:22355053]; Clin Cancer Res (2011) 17: 6398-405 [PMID:22003067]; WO2003027135. Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells. (2003) |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
