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ChEMBL ligand: CHEMBL1743043 (HA-22, Moxetumomab pasudotox-tdfk, Moxetumomab pasudotox, HA22, Lumoxiti, CAT-8015) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273] | ||||||||
GtoPdb | - | - | 8.22 | pKd | 6 | nM | Kd |
J Clin Oncol (2012) 30: 1822-8 [PMID:22355053]; Clin Cancer Res (2011) 17: 6398-405 [PMID:22003067]; WO2003027135. Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells. (2003) |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]