moxetumomab pasudotox [Ligand Id: 7675] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1743043 (CAT-8015, HA-22, HA22, Lumoxiti, Moxetumomab pasudotox, Moxetumomab pasudotox tdfk, Moxetumomab pasudotox-tdfk)
  • CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273]
GtoPdb - - 8.22 pKd 6 nM Kd J Clin Oncol (2012) 30: 1822-8 [PMID:22355053];
Clin Cancer Res (2011) 17: 6398-405 [PMID:22003067];
WO2003027135. Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells. (2003)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]