moxetumomab pasudotox [Ligand Id: 7675] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1743043 (HA-22, Moxetumomab pasudotox-tdfk, Moxetumomab pasudotox, HA22, Lumoxiti, CAT-8015)
  • CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CD22 in Human [GtoPdb: 2786] [UniProtKB: P20273]
GtoPdb - - 8.22 pKd 6 nM Kd J Clin Oncol (2012) 30: 1822-8 [PMID:22355053];
Clin Cancer Res (2011) 17: 6398-405 [PMID:22003067];
WO2003027135. Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells. (2003)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]