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ChEMBL ligand: CHEMBL2030402 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha/beta in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038477] [GtoPdb: 1551, 1549] [UniProtKB: P67870, P68400] | ||||||||
ChEMBL | Inhibition of human tertrameric CK2alphabeta holoenzyme using casein as substrate after 1 to 2 hrs by chemiluminescence assay in presence of 2 uM ATP | B | 6.67 | pIC50 | 215 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311] | ||||||||
ChEMBL | Inhibition of CDC7 in human Caco2 cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrs | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
ChEMBL | Inhibition of CDC7 in human MDA-MB-231T cells assessed as inhibition of MCM2 phosphorylation at Ser53 after 4 hrs | B | 6.93 | pIC50 | 118 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
ChEMBL | Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATP | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
GtoPdb | - | - | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human Erg | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assay | B | 7.38 | pIC50 | 42 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-3731 [PMID:22560567] |
GtoPdb | - | - | 7.38 | pIC50 | 42 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567] |
Casein kinase 2 in Human [GtoPdb: 1548] | ||||||||
GtoPdb | - | - | 6.67 | pIC50 | 215 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 3727-31 [PMID:22560567] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]