XL388 [Ligand Id: 7973] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2333365
  • 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
Created with Highcharts 10.3.3ValuesChart context menu6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
Created with Highcharts 10.3.3ValuesChart context menuALK tyrosine kinase receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
Created with Highcharts 10.3.3ValuesChart context menuAMP-activated protein kinase, beta-1 subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
Created with Highcharts 10.3.3ValuesChart context menuBR serine/threonine-protein kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
Created with Highcharts 10.3.3ValuesChart context menuCaM kinase I alphapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
Created with Highcharts 10.3.3ValuesChart context menuCaM kinase IVpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • casein kinase 1 delta/Casein kinase I delta in Human [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
Created with Highcharts 10.3.3ValuesChart context menuCasein kinase I deltapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
Created with Highcharts 10.3.3ValuesChart context menuCasein kinase IIpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuCDK3/cyclin EpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • cell division cycle 7/Cell division cycle 7-related protein kinase in Human [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
Created with Highcharts 10.3.3ValuesChart context menuCell division cycle 7-related protein kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
Created with Highcharts 10.3.3ValuesChart context menucGMP-dependent protein kinase 1 betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
Created with Highcharts 10.3.3ValuesChart context menuc-Jun N-terminal kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
Created with Highcharts 10.3.3ValuesChart context menuc-Jun N-terminal kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
Created with Highcharts 10.3.3ValuesChart context menuCyclin-dependent kinase 5/CDK5 activator 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • death associated protein kinase 2/Death-associated protein kinase 2 in Human [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
Created with Highcharts 10.3.3ValuesChart context menuDeath-associated protein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
Created with Highcharts 10.3.3ValuesChart context menuDeath-associated protein kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
Created with Highcharts 10.3.3ValuesChart context menuDiscoidin domain-containing receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
Created with Highcharts 10.3.3ValuesChart context menuDNA-dependent protein kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity mitogen-activated protein kinase kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity mitogen-activated protein kinase kinase 4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity mitogen-activated protein kinase kinase 6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity mitogen-activated protein kinase kinase 7pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
Created with Highcharts 10.3.3ValuesChart context menuDual specificity protein kinase CLK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
Created with Highcharts 10.3.3ValuesChart context menuDual-specificity tyrosine-phosphorylation regulated kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EPH receptor A2/Ephrin type-A receptor 2 in Human [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
Created with Highcharts 10.3.3ValuesChart context menuEphrin type-A receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • EPH receptor B1/Ephrin type-B receptor 1 in Human [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
Created with Highcharts 10.3.3ValuesChart context menuEphrin type-B receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
Created with Highcharts 10.3.3ValuesChart context menuEpidermal growth factor receptor erbB1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
Created with Highcharts 10.3.3ValuesChart context menuFibroblast growth factor receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
Created with Highcharts 10.3.3ValuesChart context menuFibroblast growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
Created with Highcharts 10.3.3ValuesChart context menuFibroblast growth factor receptor 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
Created with Highcharts 10.3.3ValuesChart context menuFibroblast growth factor receptor 4pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
Created with Highcharts 10.3.3ValuesChart context menuFocal adhesion kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 alphapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
Created with Highcharts 10.3.3ValuesChart context menuGlycogen synthase kinase-3 betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • G protein-coupled receptor kinase 5 in Human [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
Created with Highcharts 10.3.3ValuesChart context menuG protein-coupled receptor kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
Created with Highcharts 10.3.3ValuesChart context menuHeat shock protein HSP 90-betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
Created with Highcharts 10.3.3ValuesChart context menuHepatocyte growth factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
Created with Highcharts 10.3.3ValuesChart context menuHomeodomain-interacting protein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
Created with Highcharts 10.3.3ValuesChart context menuInhibitor of nuclear factor kappa B kinase alpha subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
Created with Highcharts 10.3.3ValuesChart context menuInhibitor of nuclear factor kappa B kinase beta subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Insulin-like growth factor I receptor in Human [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
Created with Highcharts 10.3.3ValuesChart context menuInsulin-like growth factor I receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
Created with Highcharts 10.3.3ValuesChart context menuInterleukin-1 receptor-associated kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
Created with Highcharts 10.3.3ValuesChart context menuLIM domain kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase-activated protein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase-activated protein kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase-activated protein kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase ERK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
Created with Highcharts 10.3.3ValuesChart context menuMAP kinase signal-integrating kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • misshapen like kinase 1/Misshapen-like kinase 1 in Human [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
Created with Highcharts 10.3.3ValuesChart context menuMisshapen-like kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
Created with Highcharts 10.3.3ValuesChart context menuMitogen-activated protein kinase kinase kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
Created with Highcharts 10.3.3ValuesChart context menuMitogen-activated protein kinase kinase kinase 9pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
Created with Highcharts 10.3.3ValuesChart context menuMitogen-activated protein kinase kinase kinase kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
Created with Highcharts 10.3.3ValuesChart context menuMuscle, skeletal receptor tyrosine protein kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116]
Created with Highcharts 10.3.3ValuesChart context menuNuclear receptor subfamily 2 group C member 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
Created with Highcharts 10.3.3ValuesChart context menuPAS domain-containing serine/threonine-protein kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
Created with Highcharts 10.3.3ValuesChart context menuPhosphatidylinositol 3-kinase catalytic subunit type 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
Created with Highcharts 10.3.3ValuesChart context menuPI3-kinase p110-alpha subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
Created with Highcharts 10.3.3ValuesChart context menuPI3-kinase p110-beta subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
Created with Highcharts 10.3.3ValuesChart context menuPI3-kinase p110-delta subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
Created with Highcharts 10.3.3ValuesChart context menuPI3-kinase p110-gamma subunitpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
Created with Highcharts 10.3.3ValuesChart context menuPlatelet-derived growth factor receptor betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C alphapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C deltapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C epsilonpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C etapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C gammapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C iota/Protein kinase C iota in Human [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C iotapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase D1/Protein kinase C mu in Human [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C mupKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C theta/Protein kinase C theta in Human [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C thetapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase C zetapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase N2/Protein kinase N2 in Human [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
Created with Highcharts 10.3.3ValuesChart context menuProtein kinase N2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
Created with Highcharts 10.3.3ValuesChart context menuProtein tyrosine kinase 2 betapKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
Created with Highcharts 10.3.3ValuesChart context menuProto-oncogene tyrosine-protein kinase MERpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
Created with Highcharts 10.3.3ValuesChart context menuProto-oncogene tyrosine-protein kinase ROSpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
Created with Highcharts 10.3.3ValuesChart context menuPyruvate dehydrogenase kinase isoform 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
Created with Highcharts 10.3.3ValuesChart context menuReceptor protein-tyrosine kinase erbB-2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
Created with Highcharts 10.3.3ValuesChart context menuRho-associated protein kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
Created with Highcharts 10.3.3ValuesChart context menuRho-associated protein kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 5pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
Created with Highcharts 10.3.3ValuesChart context menuRibosomal protein S6 kinase alpha 6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase 10pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase 11pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase 33pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase AKTpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase AKT2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase AKT3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Aurora-ApKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Chk1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Chk2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein kinase D2/Serine/threonine-protein kinase D2 in Human [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase D2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • histone H3 associated protein kinase/Serine/threonine-protein kinase haspin in Human [ChEMBL: CHEMBL1075163] [GtoPdb: 2028] [UniProtKB: Q8TF76]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase haspinpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase MARK1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase MST1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase NEK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase NEK7pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • nemo like kinase/Serine/threonine protein kinase NLK in Human [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine protein kinase NLKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PAK 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PAK6pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PIM1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PLK1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase PLK3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase RAFpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase RIPK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Sgk1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serum/glucocorticoid regulated kinase 2/Serine/threonine-protein kinase Sgk2 in Human [ChEMBL: CHEMBL5794] [GtoPdb: 1535] [UniProtKB: Q9HBY8]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Sgk2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase Sgk3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase SRPK3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase TAO1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase TBK1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase ULK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase VRK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • WNK lysine deficient protein kinase 2/Serine/threonine-protein kinase WNK2 in Human [ChEMBL: CHEMBL5639] [GtoPdb: 2281] [UniProtKB: Q9Y3S1]
Created with Highcharts 10.3.3ValuesChart context menuSerine/threonine-protein kinase WNK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
Created with Highcharts 10.3.3ValuesChart context menuStem cell growth factor receptorpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
Created with Highcharts 10.3.3ValuesChart context menuTestis-specific serine/threonine-protein kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine kinase non-receptor protein 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ABLpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ABL2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase BLKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase BRKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • C-terminal Src kinase/Tyrosine-protein kinase CSK in Human [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase CSKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase FESpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase HCKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ITK/TSKpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase JAK2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase LynpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase receptor FLT3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase receptor RETpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase receptor TYRO3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase receptor UFOpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase SRCpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase YESpKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
Created with Highcharts 10.3.3ValuesChart context menuTyrosine-protein kinase ZAP-70pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
Created with Highcharts 10.3.3ValuesChart context menuVascular endothelial growth factor receptor 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
  • mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
Created with Highcharts 10.3.3ValuesChart context menumechanistic target of rapamycin kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3/6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331053] [GtoPdb: 2937] [UniProtKB: Q16875]
ChEMBL Inhibition of IPFK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of ALK (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase AMP-activated non-catalytic subunit beta 1/AMP-activated protein kinase, beta-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3847] [GtoPdb: 1543] [UniProtKB: Q9Y478]
ChEMBL Inhibition of AMPK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3]
ChEMBL Inhibition of BRSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012]
ChEMBL Inhibition of CAMK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566]
ChEMBL Inhibition of CAMK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730]
ChEMBL Inhibition of CK1delta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL Inhibition of CK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cyclin dependent kinase 3/CDK3/cyclin E in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111444] [GtoPdb: 1975] [UniProtKB: O96020, P24864, Q00526]
ChEMBL Inhibition of CDK3/Cyclin E (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cell division cycle 7/Cell division cycle 7-related protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5443] [GtoPdb: 1960] [UniProtKB: O00311]
ChEMBL Inhibition of CDC7 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976]
ChEMBL Inhibition of PKG1beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983]
ChEMBL Inhibition of JNK1alpha2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of JNK1alpha1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL Inhibition of JNK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL Inhibition of CDK5/P25 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4]
ChEMBL Inhibition of DAPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Inhibition of ZIPK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832]
ChEMBL Inhibition of DDR2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase, DNA-activated, catalytic subunit/DNA-dependent protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3142] [GtoPdb: 2800] [UniProtKB: P78527]
ChEMBL Inhibition of DNA-PK (unknown origin) B 5.05 pIC50 8831 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL Inhibition of MEK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985]
ChEMBL Inhibition of MKK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564]
ChEMBL Inhibition of MKK6 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733]
ChEMBL Inhibition of MKK7beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Inhibition of CLK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL Inhibition of DYRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317]
ChEMBL Inhibition of EPHA2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762]
ChEMBL Inhibition of EPHB1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Inhibition of EGFR (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362]
ChEMBL Inhibition of FGFR1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802]
ChEMBL Inhibition of FGFR2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607]
ChEMBL Inhibition of FGFR3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455]
ChEMBL Inhibition of FGFR4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL Inhibition of FAK (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Inhibition of GSK3alpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of GSK3beta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
G protein-coupled receptor kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5678] [GtoPdb: 1469] [UniProtKB: P34947]
ChEMBL Inhibition of GRK5 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
heat shock protein 90 alpha family class B member 1/Heat shock protein HSP 90-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4303] [GtoPdb: 2907] [UniProtKB: P08238]
ChEMBL Inhibition of HSP90 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL Inhibition of MET (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
ChEMBL Inhibition of HIPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibition of IKKalpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920]
ChEMBL Inhibition of IKKbeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069]
ChEMBL Inhibition of IGF1R (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL Inhibition of IRAK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
ChEMBL Inhibition of LIMK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137]
ChEMBL Inhibition of MAPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 3/MAP kinase-activated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4670] [GtoPdb: 2095] [UniProtKB: Q16644]
ChEMBL Inhibition of MAPKAPK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41]
ChEMBL Inhibition of PRAK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL Inhibition of MAPK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9]
ChEMBL Inhibition of MNK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8]
ChEMBL Inhibition of MINK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683]
ChEMBL Inhibition of ASK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192]
ChEMBL Inhibition of MLK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851]
ChEMBL Inhibition of GCK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146]
ChEMBL Inhibition of MUSK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Testicular receptor 4/Nuclear receptor subfamily 2 group C member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5716] [GtoPdb: 614] [UniProtKB: P49116]
ChEMBL Inhibition of TAK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2]
ChEMBL Inhibition of PASK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9]
ChEMBL Inhibition of VPS34 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate after 2 hrs by luminescence assay B 5.52 pIC50 >3000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of PI3Kalpha (unknown origin) B 5.52 pIC50 >3000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL Inhibition of PI3Kbeta (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL Inhibition of PI3Kdelta (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL Inhibition of PI3Kgamma (unknown origin) B 5.3 pIC50 >5000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition of PDGFRbeta (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of PKCalpha (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of PKCbeta2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ChEMBL Inhibition of PKCbeta1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of PKCdelta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of PKCepsilon (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Inhibition of PKCeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of PKCgamma (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743]
ChEMBL Inhibition of PKCiota (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139]
ChEMBL Inhibition of PKCmu (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759]
ChEMBL Inhibition of PKCtheta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of PKCzeta (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513]
ChEMBL Inhibition of PRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289]
ChEMBL Inhibition of PYK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866]
ChEMBL Inhibition of MER (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922]
ChEMBL Inhibition of ROS (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL Inhibition of PDK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL Inhibition of ERBB2 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL Inhibition of ROCK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
ChEMBL Inhibition of ROCK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443]
ChEMBL Inhibition of p70S6K (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418]
ChEMBL Inhibition of RSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349]
ChEMBL Inhibition of RSK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812]
ChEMBL Inhibition of RSK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582]
ChEMBL Inhibition of MSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32]
ChEMBL Inhibition of RSK4 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804]
ChEMBL Inhibition of LOK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831]
ChEMBL Inhibition of LKB1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
ChEMBL Inhibition of STK33 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749]
ChEMBL Inhibition of AKT1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751]
ChEMBL Inhibition of AKT2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL Inhibition of AKT3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of Aurora kinase A (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757]
ChEMBL Inhibition of CHK1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017]
ChEMBL Inhibition of CHK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6]
ChEMBL Inhibition of PKD2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
histone H3 associated protein kinase/Serine/threonine-protein kinase haspin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075163] [GtoPdb: 2028] [UniProtKB: Q8TF76]
ChEMBL Inhibition of Haspin (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2]
ChEMBL Inhibition of MARK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043]
ChEMBL Inhibition of MST1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955]
ChEMBL Inhibition of NEK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7]
ChEMBL Inhibition of NEK7 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8]
ChEMBL Inhibition of NLK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914]
ChEMBL Inhibition of PAK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5]
ChEMBL Inhibition of PAK6 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL Inhibition of PLK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4]
ChEMBL Inhibition of PLK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049]
ChEMBL Inhibition of cRAF (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353]
ChEMBL Inhibition of RIPK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
ChEMBL Inhibition of SGK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase 2/Serine/threonine-protein kinase Sgk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5794] [GtoPdb: 1535] [UniProtKB: Q9HBY8]
ChEMBL Inhibition of SGK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1]
ChEMBL Inhibition of SGK3 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1]
ChEMBL Inhibition of MSSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
ChEMBL Inhibition of TAO1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL Inhibition of TBK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL Inhibition of ULK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07]
ChEMBL Inhibition of VRK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
WNK lysine deficient protein kinase 2/Serine/threonine-protein kinase WNK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5639] [GtoPdb: 2281] [UniProtKB: Q9Y3S1]
ChEMBL Inhibition of WNK2 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721]
ChEMBL Inhibition of KIT (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7]
ChEMBL Inhibition of TSSK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912]
ChEMBL Inhibition of ACK1 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL Inhibition of ABL (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684]
ChEMBL Inhibition of ARG (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451]
ChEMBL Inhibition of BLK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882]
ChEMBL Inhibition of BRK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240]
ChEMBL Inhibition of CSK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332]
ChEMBL Inhibition of FES (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631]
ChEMBL Inhibition of HCK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL Inhibition of ITK (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL Inhibition of JAK2 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948]
ChEMBL Inhibition of LYN (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Inhibition of FLT3 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949]
ChEMBL Inhibition of RET (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418]
ChEMBL Inhibition of RSE (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530]
ChEMBL Inhibition of AXL (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL Inhibition of SRC (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947]
ChEMBL Inhibition of YES (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL Inhibition of ZAP70 (unknown origin) B 5 pIC50 >10000 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL Inhibition of FLT1 (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL Inhibition of KDR (unknown origin) B 5.46 pIC50 >3500 nM IC50 J Med Chem (2013) 56: 2218-2234 [PMID:23394126]
mechanistic target of rapamycin kinase in Human [GtoPdb: 2109] [UniProtKB: P42345]
GtoPdb - - 8 pIC50 9.9 nM IC50 J Med Chem (2013) 56: 2218-34 [PMID:23394126]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]