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protein kinase AMP-activated non-catalytic subunit beta 1

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Target not currently curated in GtoImmuPdb

Target id: 1543

Nomenclature: protein kinase AMP-activated non-catalytic subunit beta 1

Abbreviated Name: AMPKB1

Family: AMPK subfamily

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 270 12q24.23 PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1
Mouse - 270 5 F Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
Rat - 270 12q16 Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1
Previous and Unofficial Names Click here for help
AMPK beta 1 | 5'-AMP-activated protein kinase 40 kDa subunit | AMPKb | protein kinase, AMP-activated, beta 1 non-catalytic subunit | protein kinase
Database Links Click here for help
Alphafold Q9Y478 (Hs), Q9R078 (Mm), P80386 (Rn)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL3847 (Hs), CHEMBL3885503 (Rn)
DrugBank Target Q9Y478 (Hs)
Ensembl Gene ENSG00000111725 (Hs), ENSMUSG00000029513 (Mm), ENSRNOG00000001142 (Rn)
Entrez Gene 5564 (Hs), 19079 (Mm), 83803 (Rn)
Human Protein Atlas ENSG00000111725 (Hs)
KEGG Gene hsa:5564 (Hs), mmu:19079 (Mm), rno:83803 (Rn)
OMIM 602740 (Hs)
Pharos Q9Y478 (Hs)
RefSeq Nucleotide NM_006253 (Hs), NM_031869 (Mm), NM_031976 (Rn)
RefSeq Protein NP_006244 (Hs), NP_114075 (Mm), NP_114182 (Rn)
UniProtKB Q9Y478 (Hs), Q9R078 (Mm), P80386 (Rn)
Wikipedia PRKAB1 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
MT47-100 Small molecule or natural product Click here for species-specific activity table Hs Activation 5.4 pKi 1
⤷ pKi 5.4 (Ki 3.7x10-6 M) [1]

References

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1. Scott JW, Galic S, Graham KL, Foitzik R, Ling NX, Dite TA, Issa SM, Langendorf CG, Weng QP, Thomas HE et al.. (2015) Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release. Chem Biol, 22 (6): 705-11. [PMID:26091167]

How to cite this page

AMPK subfamily: protein kinase AMP-activated non-catalytic subunit beta 1. Last modified on 30/03/2016. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1543.