Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	798	17p13.2	HASPIN	histone H3 associated protein kinase
Mouse	-	754	11 45.25 cM	Haspin	histone H3 associated protein kinase

Previous and Unofficial Names

Germ cell-specific gene 2 protein | Haploid germ cell-specific nuclear protein kinase | haspin | Serine/threonine-protein kinase haspin | germ cell associated 2 (haspin) | germ cell-specific gene 2 | GSG2 | germ cell associated 2, haspin | Gsg2

Database Links
Alphafold	Q8TF76 (Hs), Q9Z0R0 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL1075163 (Hs)
Ensembl Gene	ENSG00000177602 (Hs), ENSMUSG00000050107 (Mm)
Entrez Gene	83903 (Hs), 14841 (Mm)
Human Protein Atlas	ENSG00000177602 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:83903 (Hs), mmu:14841 (Mm)
OMIM	609240 (Hs)
Pharos	Q8TF76 (Hs)
RefSeq Nucleotide	NM_031965 (Hs), NM_010353 (Mm)
RefSeq Protein	NP_114171 (Hs), NP_034483 (Mm)
UniProtKB	Q8TF76 (Hs), Q9Z0R0 (Mm)
Wikipedia	HASPIN (Hs)

Selected 3D Structures
	Description:  Crystal structure of haspin kinase PDB Id:  2WB8 Resolution:  2.15Å Species:  Human References:  4
	Description:  Crystal Structure of Human Haspin with an Imidazo-pyridazine ligand PDB Id:  3F2N Resolution:  1.8Å Species:  Human References:

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference SGI-1776 Hs Inhibition 7.5 pIC50 2 ⤷ pIC50 7.5 (IC50 3.4x10-8 M) [2]

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,3
Key to terms and symbols		Click column headers to sort
Target used in screen: Haspin/Haspin
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM PKR inhibitor Hs Inhibitor Inhibition 5.7 3.0 1.0 staurosporine Hs Inhibitor Inhibition 6.9 1.0 2.5 PKR inhibitor, negative control Hs Inhibitor Inhibition 8.7 12.0 1.0 K-252a Hs Inhibitor Inhibition 10.2 8.0 5.0 SB 218078 Hs Inhibitor Inhibition 18.5 50.0 22.0 JAK3 inhibitor VI Hs Inhibitor Inhibition 22.5 9.0 1.0 Cdc2-like kinase inhibitor Hs Inhibitor Inhibition 25.0 17.0 4.0 Gö 6976 Hs Inhibitor Inhibition 27.2 11.0 8.0 JNK inhibitor V Hs Inhibitor Inhibition 31.0 36.0 -2.0 indirubin derivative E804 Hs Inhibitor Inhibition 32.8 13.0 11.0
Displaying the top 10 most potent ligands  View all ligands in screen »