The IUPHAR Guide to IMMUNOPHARMACOLOGY Disease list

List of immunological diseases and the ligands contained in GtoPdb they are associated with.
Disease: Activated PI3K delta syndrome 1 ligand association: nemiralisib more details »
Disease X-Refs: OMIM: 615513
Orphanet: ORPHA397596

Disease: Acute lymphocytic leukemia (ALL) 1 ligand association: blinatumomab more details »
Disease X-Refs: OMIM: 613065

Disease: Acute myeloid leukemia 4 ligand associations: midostaurin; gemtuzumab ozogamicin; crenolanib; vadastuximab talirine more details »
Disease X-Refs: Disease Ontology: DOID:9119
OMIM: 601626
Orphanet: ORPHA519

Disease: Adult T-cell leukemia 1 ligand association: mogamulizumab more details »
Disease X-Refs: Disease Ontology: DOID:0050523

Disease: Allergic conjunctivitis 6 ligand associations: fluorometholone; loteprednol etabonate; diphenylpyraline; alcaftadine; cromoglicic acid; navamepent more details »
Disease X-Refs: Disease Ontology: DOID:11204

Disease: Allergic rhinitis 12 ligand associations: fexofenadine; clemastine; fluticasone propionate; azatadine; desloratadine; diphenylpyraline; loratadine; tripelennamine ... more details »
Disease X-Refs: Disease Ontology: DOID:4481

Disease: Allergic urticaria 9 ligand associations: fexofenadine; clemastine; tripelennamine; amcinonide; fluocinolone acetonide; fluocinonide; azatadine; desloratadine ... more details »
Disease X-Refs: Disease Ontology: DOID:10612

Disease: Alopecia areata 2 ligand associations: tralokinumab; PF-06651600 more details »
Disease X-Refs: Disease Ontology: DOID:986

Disease: Anaphylactic shock 1 ligand association: (-)-adrenaline more details »
Disease X-Refs: Disease Ontology: DOID:0060056

Disease: Anaplastic large cell lymphoma 1 ligand association: brentuximab vedotin more details »
Disease X-Refs: Disease Ontology: DOID:0050744

Disease: Ankylosing spondylitis 14 ligand associations: adalimumab; filgotinib; etoricoxib; flurbiprofen; IL-17A; naproxen; sulindac; golimumab ... more details »
Disease X-Refs: Disease Ontology: DOID:7147

Disease: Aspirin exacerbated respiratory diseases 1 ligand association: CCL24 more details »
Disease X-Refs:

Disease: Asthma 72 ligand associations: tamatinib; risankizumab; tiotropium; theophylline; salbutamol; salmeterol; ipratropium; cetirizine ... more details »
Disease X-Refs: Disease Ontology: DOID:2841
OMIM: 600807

Disease: Atopic dermatitis 11 ligand associations: tralokinumab; cortisol; IL-31; dupilumab; JNJ-39758979; tezepelumab; ZPL-3893787; crisaborole ... more details »
Disease X-Refs: Disease Ontology: DOID:3310
OMIM: 603165

Disease: Autoimmune lymphoproliferative syndrome; ALPS 1 ligand association: Fas ligand more details »
Disease X-Refs: Disease Ontology: DOID:6688
OMIM: 601859
Orphanet: ORPHA3261

Disease: Autoimmune thrombocytopenic purpura 2 ligand associations: prednisolone; deflazacort more details »
Disease X-Refs: Disease Ontology: DOID:8924
OMIM: 188030
Orphanet: ORPHA3002

Disease: B-cell chronic lymphocytic leukemia 5 ligand associations: lenzilumab; spebrutinib; bafetinib; acalabrutinib; RG7845 more details »
Disease X-Refs: OMIM: 151400
Orphanet: ORPHA67038

Disease: B-cell lymphoma 2 ligand associations: spebrutinib; RG7845 more details »
Disease X-Refs: Disease Ontology: DOID:707

Disease: Bronchospasm 1 ligand association: salbutamol more details »
Disease X-Refs: Disease Ontology: DOID:1176

Disease: Chronic granulomatous disease 1 ligand association: IFN-γ more details »
Disease X-Refs: Disease Ontology: DOID:3265
Orphanet: ORPHA379

Disease: Chronic idiopathic urticaria 2 ligand associations: omalizumab; loratadine more details »
Disease X-Refs:

Disease: Chronic lymphocytic leukemia 7 ligand associations: ofatumumab; veltuzumab; idelalisib; rituximab; ibrutinib; obinutuzumab; milatuzumab more details »
Disease X-Refs: Disease Ontology: DOID:1040
OMIM: 151400
Orphanet: ORPHA67038

Disease: Chronic myelogenous leukemia 1 ligand association: imatinib more details »
Disease X-Refs: Disease Ontology: DOID:8552
OMIM: 608232

Disease: Chronic obstructive pulmonary disease 41 ligand associations: salbutamol; glycopyrrolate; abediterol; theophylline; salmeterol; ipratropium; tiotropium; prednisolone ... more details »
Disease X-Refs: Disease Ontology: DOID:3083

Disease: CINCA syndrome 1 ligand association: rilonacept more details »
Disease X-Refs: OMIM: 607115
Orphanet: ORPHA1451

Disease: Colitis 5 ligand associations: triamcinolone; methylprednisolone; bihelical apoA-I mimetic peptide 5A; compound 24 [PMID: 26987013 ]; PRN694 more details »
Disease X-Refs:

Disease: Crohn's disease 23 ligand associations: ozanimod; natalizumab; prednisolone; adalimumab; infliximab; certolizumab pegol; azathioprine; vedolizumab ... more details »
Disease X-Refs: Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206

Disease: Cutaneous T cell lymphoma 1 ligand association: denileukin diftitox more details »
Disease X-Refs: Disease Ontology: DOID:0060061

Disease: Dermatitis 14 ligand associations: cortisol; amcinonide; betamethasone; clobetasol propionate; desonide; desoximetasone; diflorasone diacetate; fluocinolone acetonide ... more details »
Disease X-Refs: Disease Ontology: DOID:2723

Disease: Diabetes mellitus, type 2 1 ligand association: alvelestat more details »
Disease X-Refs: Disease Ontology: DOID:9352

Disease: Duchenne muscular dystrophy 2 ligand associations: deflazacort; naproxcinod more details »
Disease X-Refs: Disease Ontology: DOID:11723
OMIM: 19518854

Disease: Eosinophilic esophagitis 1 ligand association: dectrekumab more details »
Disease X-Refs: Disease Ontology: DOID:13922
Orphanet: ORPHA73247

Disease: Familial cold autoinflammatory syndrome 1; FCAS1 3 ligand associations: IL-1β; canakinumab; rilonacept more details »
Disease X-Refs: OMIM: 120100
Orphanet: ORPHA47045

Disease: Follicular lymphoma 1 ligand association: obinutuzumab more details »
Disease X-Refs: Disease Ontology: DOID:0050873

Disease: Gout 3 ligand associations: etoricoxib; naproxen; sulindac more details »
Disease X-Refs: Disease Ontology: DOID:13189

Disease: Graft versus host disease 8 ligand associations: alvelestat; itacitinib; cyclosporin A; sirolimus; basiliximab; muromonab-CD3; belatacept; KD025 more details »
Disease X-Refs:

Disease: Graves' disease 1 ligand association: methimazole more details »
Disease X-Refs: Disease Ontology: DOID:12361

Disease: Hereditary angioedema 2 ligand associations: icatibant; ecallantide more details »
Disease X-Refs: Disease Ontology: DOID:14735
OMIM: 106100, 610618

Disease: Hypereosinophilic syndrome, idiopathic; HES 1 ligand association: mepolizumab more details »
Disease X-Refs: OMIM: 607685
Orphanet: ORPHA3260

Disease: Idiopathic pulmonary fibrosis 4 ligand associations: pirfenidone; lebrikizumab; KD025; GLPG1690 more details »
Disease X-Refs: Disease Ontology: DOID:0050156
Orphanet: ORPHA2032

Disease: Inflammatory bowel disease 1; IBD1 8 ligand associations: BMS-561392; 3beta-Hydroxy-20(29)-lupene; MRL-367; MRL-248; GSK583; bihelical apoA-I mimetic peptide 5A; etrasimod; PF-06651600 more details »
Disease X-Refs: Disease Ontology: DOID:0050589
OMIM: 266600

Disease: Interstitial cystitis 1 ligand association: rosiptor more details »
Disease X-Refs: Disease Ontology: DOID:13949

Disease: Juvenile idiopathic arthritis 2 ligand associations: ibuprofen; methotrexate more details »
Disease X-Refs:

Disease: Juvenile idiopathic arthritis- systemic 5 ligand associations: IL-1β; canakinumab; tocilizumab; abatacept; deflazacort more details »
Disease X-Refs: OMIM: 604302

Disease: keratoconjunctivitis sicca 2 ligand associations: lifitegrast; navamepent more details »
Disease X-Refs: Disease Ontology: DOID:12895

Disease: Localized scleroderma 1 ligand association: CXCL9 more details »
Disease X-Refs: Disease Ontology: DOID:8472

Disease: Lupus erythematosus 2 ligand associations: triamcinolone; ACTH more details »
Disease X-Refs: Disease Ontology: DOID:8857

Disease: Lymphoma, Hodgin, Classic; CHL 2 ligand associations: brentuximab vedotin; nivolumab more details »
Disease X-Refs: Disease Ontology: DOID:8567
OMIM: 236000

Disease: Lymphoma, non-hodgkin, familial 2 ligand associations: IL-21; lymphotoxin-α more details »
Disease X-Refs: Disease Ontology: DOID:0060060
OMIM: 605027

Disease: Mantle cell lymphoma 1 ligand association: ibrutinib more details »
Disease X-Refs: Disease Ontology: DOID:0050746
Orphanet: ORPHA52416

Disease: Mastocytosis 3 ligand associations: midostaurin; masitinib; cromoglicic acid more details »
Disease X-Refs: Disease Ontology: DOID:350

Disease: Muckle-Wells syndrome 3 ligand associations: IL-1β; canakinumab; rilonacept more details »
Disease X-Refs: OMIM: 191900
Orphanet: ORPHA575

Disease: Multicentric Castleman disease 1 ligand association: siltuximab more details »
Disease X-Refs: OMIM: 148000
Orphanet: ORPHA93686

Disease: Multiple myeloma 4 ligand associations: plerixafor; masitinib; daratumumab; elotuzumab more details »
Disease X-Refs: Disease Ontology: DOID:9538
OMIM: 254500

Disease: Multiple Sclerosis 4 ligand associations: IFN-β1b (recombinant human); ACTH; IL-17A; ROMe more details »
Disease X-Refs: Disease Ontology: DOID:2377
OMIM: 126200
Orphanet: ORPHA802

Disease: Myelodysplastic syndrome 2 ligand associations: azacitidine; talmapimod more details »
Disease X-Refs: Disease Ontology: DOID:0050908
OMIM: 614286

Disease: Myelofibrosis 2 ligand associations: ruxolitinib; itacitinib more details »
Disease X-Refs: Disease Ontology: DOID:4971
OMIM: 254450
Orphanet: ORPHA824

Disease: Myositis 1 ligand association: belimumab more details »
Disease X-Refs: Disease Ontology: DOID:633
OMIM: 160750

Disease: non-Hodgkin lymphoma 5 ligand associations: plerixafor; IL-2; idelalisib; ibritumomab tiuxetan; tositumomab more details »
Disease X-Refs: Disease Ontology: DOID:0060060
OMIM: 605027

Disease: Osteoarthritis 22 ligand associations: piclidenoson; fenoprofen; PF-04905428; mefenamic acid; ibuprofen; triamcinolone; rofecoxib; etoricoxib ... more details »
Disease X-Refs: Disease Ontology: DOID:8398