Targets Associated to Immuno Cell Types - Dendritic cells

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The Dendritic cells category includes the following Cell Ontology parent terms:

dendritic cell (CL:0000451) - A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).

GPCRs
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
5-HT1B receptor
(5-Hydroxytryptamine receptors)
Involved in DC chemotaxis.
  • dendritic cell (CL:0000451)
5-ht1e receptor
(5-Hydroxytryptamine receptors)
Involved in DC chemotaxis.
  • dendritic cell (CL:0000451)
5-HT2A receptor
(5-Hydroxytryptamine receptors)
Involved in chemokine production.
  • dendritic cell (CL:0000451)
The chemoattractant properties of 5-HT on human eosinophils is mediated by 5-HT2A receptor [12] ...
5-HT2B receptor
(5-Hydroxytryptamine receptors)
  • dendritic cell (CL:0000451)
5-HT4 receptor
(5-Hydroxytryptamine receptors)
Involved in cytokine production/release from DCs.
  • dendritic cell (CL:0000451)
5-HT has been shown to alter cytokine production by dendritic cells via 5-HT4 and 5-HT7 receptors [2] ...
5-HT7 receptor
(5-Hydroxytryptamine receptors)
Involved in cytokine production/release from DCs.
  • dendritic cell (CL:0000451)
5-HT has been shown to alter cytokine production by dendritic cells via 5-HT4 and 5-HT7 receptors [2] ...
CXCR3
(Chemokine receptors)
N.B. inflammatory dentritic cells
    CXCR3 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. CXCR3 is the receptor for CXCL9, -10 and -11, three CXC chemokines that are preferentially expressed on Th1 lymphocytes.
    XCR1
    (Chemokine receptors)
    Human XCR1 is expressed exclusively in CD141+ (BDCA3+) DCs, and in mouse expression is restricted to CD8+ DCs which are phenotypically similar to the human cells. XCR1 is NOT expressed in T cells, B cells, NK cells, granulocytes, monocytes, or other DC subsets.
    • CD141-positive myeloid dendritic cell (CL:0002394)
    XCR1 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. Chemokines primarily act to promote leukocyte chemotaxis to sites of inflammation. XCR1 is expressed by a subset of dendritic cells [35] ...
    Enzymes
    GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
    Haem oxygenase 1
    (Haem oxygenase)
    HO1 expression inhibits dendritic cell maturation and secretion of proinflammatory cytokines.
    • immature conventional dendritic cell (CL:0000840)
    Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO).

    Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation.

    HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [4] ...
    FGR proto-oncogene, Src family tyrosine kinase
    (Src family)
    • dendritic cell (CL:0000451)
    Fgr may be involved in neutrophil migration, potentially via binding to intergrins [9] ...
    HCK proto-oncogene, Src family tyrosine kinase
    (Src family)
      Hck is thought to be involved in neutrophil migration, potentially via binding to intergrins [9] ...
      LYN proto-oncogene, Src family tyrosine kinase
      (Src family)
      • dendritic cell (CL:0000451)
      LYN is a Src family tyrosine kinase, expressed predominantly in hematopoietic cells, but also in neural, liver, and adipose tissues. LYN appears to function as a rheostat to modulate B cell signaling, and can be activating or inhibitory in action, depending on the B cell receptor and interacting protein complement present in particular cells [21-22,52] ...
      SRC proto-oncogene, non-receptor tyrosine kinase
      (Src family)
      • dendritic cell (CL:0000451)
      Src family tyrosine kinases act as general modulators of immune cell signaling, playing diverse signaling functions, both inhibitory and stimulatory, in immunoreceptor and integrin signaling pathways [39] ...
      Catalytic Receptors
      GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
      TLR6
      (Toll-like receptor family)
      NB monocyte-derived immature DCs.
      • dendritic cell (CL:0000451)
      TLR6 forms heterodimers with TLR2 to detect a wide range of bacterial lipopeptides from bacterial cell membranes, and effect an immune response [20] ...
      CIITA
      (NOD-like receptor family)
      CIITA is the master regulator of MHC-II expression on antigen-presenting cells.
      • dendritic cell (CL:0000451)
      CIITA is a transcriptional coactivator for the transcription factor RFX5 [48] ...
      MER proto-oncogene, tyrosine kinase
      (Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family)
      • dendritic cell (CL:0000451)
      Mer plays a critical role in regulating self-tolerance mediated between apoptotic cells, dendritic cells, and T cells [11,53] ...
      Transporters
      GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
      Peptide transporter 3
      (SLC15 family of peptide transporters)
      • dendritic cell (CL:0000451)
      SLC15A3 and SLC15A4, are preferentially expressed by dendritic cells, especially after TLR stimulation [43] ...
      Peptide transporter 4
      (SLC15 family of peptide transporters)
      • dendritic cell (CL:0000451)
      SLC15A3 and SLC15A4, are preferentially expressed by dendritic cells, especially after TLR stimulation [43] ...
      Other Protein Targets
      GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
      CD33
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD33 (SIGLEC-3) is a myeloid cell I-type (Ig-type) lectin that binds glycans containing sialic acids [23] ...
      CS1 (CD319)
      (CD molecules)
      • dendritic cell (CL:0000451)
      CS1 is a member of the signalling lymphocyte activation molecule (SLAM) receptor family. CS1 is a membrane glycoprotein primarily expressed on plasma cells. Homophilic interaction (i.e. interaction with itself) of CS1 induces B cell proliferation and autocrine cytokine secretion, thus playing a role in various immune functions.

      CS1 is a validated molecular target for the development of novel immunotherapeutics with the potential to treat MM, a malignant disease of plasma cells which remains incurable despite advances in treatment (such as bortezomib, lenalidomide and immunotherapies in clinical trial). Indeed, a combination therapy containing the anti-CS1 mAb elotuzumab (elotuzumab + lenalidomide + dexamethasone), was FDA approved for MM in 2015. CS1 expression is also elevated in patients with systemic lupus erythematosus (SLE) [33] ...
      regulator of G-protein signaling 13
      (R4 family)
      NB mouse dendritic cells.
      • dendritic cell (CL:0000451)
      RGS13 inhibits CXCL12- and CXCL13-induced MAPK activation, and chemotaxis [50] ...
      C-type lectin domain family 4 member A
      (C-type lectin-like receptors (CLRs))
      • dendritic cell (CL:0000451)
      C-type lectin domain family 4 member E
      (C-type lectin-like receptors (CLRs))
      • dendritic cell (CL:0000451)
      Mincle is an FcRγ-associated membrane receptor involved in initiating the innate immune response upon recognition of endogenous and exogenous ligands including Sin3A-associated protein (SAP130), α-mannan on fungal cell walls and mycobacterial cord factor (trehalose-6,6′-dimycolate (TDM)) [14] ...
      CD38
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD38 is a type II transmembrane glycoprotein, widely expressed on immune cells and involved in cell adhesion and signal transduction. Its extracellular domain acts as an ectoenzyme, catalyzing the conversion of nicotinamide adenine dinucleotide (NAD+) into nicotinamide, adenosine diphosphate-ribose (ADPR), and cyclic ADPR. Expression of CD38 is tightly regulated during B-cell development and maturation [24] ...
      CD74
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD74 is a type II transmembrane glycoprotein which associates with the MHC class II α and β chains and directs the transport of class II molecules to lysosomal and endosomal compartments [17] ...
      CD80
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD80 (B7-1) is expressed on dendritic cells and activated B cells and monocytes. It is required to provide a costimulatory signal necessary for T cell activation and survival. CD80 works in concert with CD86 to prime T cells. CD80 binds CD28 and CTLA-4 on T cells. It is the interaction with CTLA-4 t ...
      LILRA4 (CD85g)
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD85g is involved in activation of eosinophils and homeostatic regulation of the innate immunity of plasmacytoid dendritic cells (pDCs) [15] ...
      CD86
      (CD molecules)
      • dendritic cell (CL:0000451)
      CD86 (B7-2) is a type I membrane immunoglobulin. It is expressed on antigen-presenting cells and in association with CD80 provides the costimulatory signal necessary for T cell activation and survival. CD86 interacts with CD28 or CTLA-4 on T cells. It is the interaction with CTLA-4 that is targeted ...
      programmed cell death 1 ligand 1 (CD274)
      (CD molecules)
      • dendritic cell (CL:0000451)
      PD-L1 is an endogenous ligand of the checkpoint receptor programmed cell death 1 (PD-1). Engagement of PD-1 by PD-L1 has immunosuppressive action. Both the ligand and receptor are being pursued as targets for novel oncology therapeutics, as over-expression of either of these proteins is a mechanism used by tumour cells to evade immune detection and destruction. Antibody-based therapies targeting the PD-1/PD-L1 pathway augment immune responses and eliminate tumour-induced tolerance. Clinically this action has been observed as regression in various tumour types, including melanoma, renal cell carcinoma [45] ...
      CD300a
      (CD molecules)
      • plasmacytoid dendritic cell (CL:0000784)
      CD300a is a member of the CD300 family of leucocyte surface receptors [13] ...