Synonyms: GBP
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Gal-1 is a mammalian lectin that is active in the immune system. Its participation in the induction of self-tolerance suggests that any altered activity could lead to a failure to select out autoreactive cells, which may be relevant to autoimmune disease pathogenesis.
Species: Human
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Immunopharmacology Comments |
Gal-1 is a mammalian lectin that modulates T cell function and apoptosis. Gal-1 (expressed by stromal cells) is also required for the development of B cells in the bone marrow [3] and contributes to the induction of B cells regulatory function [1]. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Graft versus host disease | Gal-1 reduces host alloreactivity and suppresses the graft versus host immune response in animal GvHD models, leading to increased survival. | 2 |