romiplostim

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Ligands
romiplostim

GtoPdb Ligand ID: 6974

Synonyms: MG531 | Nplate®

romiplostim is an approved drug (FDA (2008), EMA (2009))

Compound class: Peptide or derivative

Comment: This drug is a thrombopoietin receptor agonist, although its peptide sequence does not resemble that of the endogenous peptide thrombopoietin. Romiplostim is known as a peptibody, a fusion between the Fc portion of immunoglobulin and a therapeutic peptide. In this case the drug exists as a heterodimer. The carboxy terminal 14 amino acid residues of this peptibody constitute the thrombopoietin receptor binding domain (single letter amino acid code: IEGPTLRQWLAARA).

Immunopharmacology Comments
Increases the platelet count in ITP patients via activation of the thrombopoietin receptor to combat the autoimmune destruction of platelets in this disease.

Immunopharmacology Comments

Increases the platelet count in ITP patients via activation of the thrombopoietin receptor to combat the autoimmune destruction of platelets in this disease.

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Autoimmune thrombocytopenic purpura	Disease Ontology: DOID:8924 OMIM: 188030 Orphanet: ORPHA3002	Approved drug for autoimmune thrombocytopenic purpura (a.k.a. idiopathic thrombocytopenic purpura)