inotuzumab ozogamicin   Click here for help

GtoPdb Ligand ID: 8266

Synonyms: Besponsa® | CMC-544
Approved drug Immunopharmacology Ligand
inotuzumab ozogamicin is an approved drug (EMA & FDA (2017))
Compound class: Antibody
Comment: Inotuzumab ozogamicin is an antibody-drug conjugate (ADC) that targets delivery of the highly cytotoxic ozogamicin (a derivative of calicheamicin γ1) to CD22 (SIGLEC-2) +ve myeloid cells [1]. The calicheamicin derivative is N-acetyl gamma calicheamicin dimethylhydrazide as reported by DiJoseph et al (2004) [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
Inotuzumab ozogamicin is an immuno-oncology drug that blocks the inhibitory SIGLEC-2/sialic acid-containing glycans B cell checkpoint, an action that restores immune cell activation, and simultaneously delivers a toxic payload to CD-22-targeted cancer cells.
Immunopharmacology Disease
Disease X-Refs Comment References
Acute lymphocytic leukemia (ALL) OMIM: 613065
 Approved therapy for ALL.