Synonyms: ABT-981 | E26.13-SS-X3 [6]
Compound class:
Antibody
Comment: Lutikizumab (ABT-981) is an investigational monoclonal antibody targeting IL-1α and IL-1β [6], designed using proprietary technology to create dual variable domain antibodies ('DVD-IgTM') [3]. DVD-Igs are single pharmaceutical agents capable of simultaneously targeting two mediators of disease. The unique feature of DVD-Igs is that each arm of the antibody contains two tandem variable domains, each capable of binding a different antigen (see Figure 2 in [6]).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
Immunopharmacology Comments |
Lutikizumab (ABT-981) potently neutralizes biological activity of both IL-1α and IL-1β [6]. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Osteoarthritis |
Disease Ontology:
DOID:8398 |
Phase 2 clinical candidate for OA. |