Synonyms: RX-10045
Compound class:
Synthetic organic
Comment: Navamepent (RX-10045) is a stable resolvin E1 analogue, that is being investigated for clinical efficacy in occular inflammation [3]. Chemically this is an isopropyl ester prodrug of resolvin E1 (an agonist of the chemerin receptor). The chemical structure is claimed in patent US20140275247A1 (as Example 1001) [2]. Findings from animal studies are reported in [1] and [4].
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Immunopharmacology Comments |
A metabolically stable resolvin E1 analogue, that has completed Phase 2 clinical evaluation in several occular inflammation conditions. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Allergic conjunctivitis |
Disease Ontology:
DOID:11204 |
Phase 2 clinical trial NCT01639846 has been completed. | |
keratoconjunctivitis sicca |
Disease Ontology:
DOID:12895 |
Phase 2 clinical trials NCT00799552 and NCT01675570 are completed. |