Immuno Cell Types

The Guide to IMMUNOPHARMACOLOGY provides lists of targets associated to top-level cell type categories. These categories are described below, showing Cell Ontology terms (and definitions) that have been assigned to them. Click on the category title to view the detailed list of target associations. The GtoImmuPdb help pages provide more information.

Jump to: B cells | T cells | Dendritic cells | Other T cells | Macrophages & monocytes | Granulocytes | Natural killer cells | Mast cells | Innate lymphoid cells | Stromal cells |

B cells

The B cells category includes the following Cell Ontology parent terms:

lymphocyte of B lineage (CL:0000945) - A lymphocyte of B lineage is a lymphocyte that expresses CD19 on the cell surface. An additional defining characteristic is the commitment to express an immunoglobulin complex. Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).


T cells

The T cells category includes the following Cell Ontology parent terms:

alpha-beta T cell (CL:0000789) - A T cell that expresses an alpha-beta T cell receptor complex.
effector T cell (CL:0000911) - A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.
regulatory T cell (CL:0000815) - A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.

This should encompass most cytotoxic and helper T cells, as well as regulatory T cells.


Dendritic cells

The Dendritic cells category includes the following Cell Ontology parent terms:

dendritic cell (CL:0000451) - A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).


Other T cells

The Other T cells category includes the following Cell Ontology parent terms:

gamma-delta T cell (CL:0000798 - A T cell that expresses a gamma-delta (γδ) T cell receptor complex. A major subset of human γδ T cells express Vγ2Vδ2 TCRs (also termed Vγ9Vδ2 TCRs).
memory T cell (CL:0000814) - A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.
naive T cell (CL:0000898) - Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
mucosal invariant T cell (CL:0000940) - An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule.

This should encompass natural killer T cells, mucosal associated invariant T cells & memory T cells


Macrophages & monocytes

The Macrophages & monocytes category includes the following Cell Ontology parent terms:

macrophages (CL:0000235) - A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
monocytes (CL:0000576) - Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.


Granulocytes

The Granulocytes category includes the following Cell Ontology parent terms:

granulocytes (CL:0000094) - A leukocyte with abundant granules in the cytoplasm. Synonyms: granular leukocyte, polymorphonuclear leukocyte.


Natural killer cells

The Natural killer cells category includes the following Cell Ontology parent terms:

natural killer cell (CL:0000623) - A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.


Mast cells

The Mast cells category includes the following Cell Ontology parent terms:

mast cell (CL:0000097) - A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.


Innate lymphoid cells

The Innate lymphoid cells category includes the following Cell Ontology parent terms:

innate lymphoid cell (CL:0001065) - A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.


Stromal cells

The Stromal cells category includes the following Cell Ontology parent terms:

stromal cell (CL:0000499) - A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.