The IUPHAR Guide to IMMUNOPHARMACOLOGY

Background

The Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb) is a Wellcome Trust-funded extension to the existing Guide to PHARMACOLOGY (GtoPdb). The development of GtoImmuPdb aims to provide improved data exchange between immunology and pharmacology expert communities, so to better support research and development of drugs targeted at modulating immune, inflammatory or infectious components of disease.

The underlying GtoPdb schema has been extended to incorporate new immune system specific data types (such as processes and cell types) and the GtoPdb website has been developed to surface this new data and incorporate it into the existing search and browse mechanisms. A new Guide to IMMUNOPHARMACOLOGY portal has been developed, which serves as a unique immunological access-point to the Guide to PHARMACOLOGY.

Click here to access the database

For more information on the parent Guide to PHARMACOLOGY see the About page and the FAQ.

Contact us

If you would like to get in touch with any comments, questions, error reports and suggestions please email us.

How to cite

Please refer to this page for details on how to cite the information contained in the Guide to PHARMACOLOGY and the Guide to IMMUNOPHARMACOLOGY

The Data in the Guide to IMMUNOPHARMACOLOGY

Immunological Process Data

GtoImmuPdb contains data detailing immunological processes and their associations to GtoPdb targets.

GtoImmuPdb has defined its own set of top-level immunological process categories against which targets in the database can be annotated and which form the basis of organising, navigating and searching for immunological processes and associations.

In addition, GtoImmuPdb uses terms from the Gene Ontology (GO) to help annotated targets to these categories.

Full documentation can be found in this GtoImmuPdb immuno process data documentation (PDF).

Excel speadsheet listing annotations of GtoPdb targets versus immuno process categories: UniProt_GO_Annotation_in_GtoImmuPdb.xls

Cell Type Data

GtoImmuPdb contains data detailing immunological cell types and their associations to GtoPdb targets. The Cell Ontology provides the formalised vocabulary against which we annotated target to cell type associations

GtoImmuPdb has defined its own set of top-level immunological cell type categories against which targets in the database can be annotated and which form the basis of organising, navigating and searching for immunological cell types and associations.

Full documentation can be found in this GtoImmuPdb immuno cell tpye data documentation (PDF).

Disease Data

GtoImmuPdb contains data detailing diseases and their associations to GtoPdb targets and ligands. The database currently maps these disease terms to 3 external resources: OMIM, Orphanet and the Disease Ontology. These resource help provide a formalised vocabulary against which we can annotated targets and ligands to diseases.

Full documentation can be found in this GtoImmuPdb immuno disease data documentation (PDF).

About IUPHAR

Founded in 1959 as a section of the International Union of Physiological Sciences, the International Union of Basic and Clinical Pharmacology (IUPHAR) has been independent since 1966. IUPHAR is a member of the International Council for Science (ICSU) and participates in the work of its scientific committees. It receives international recognition, particularly by the United Nations Educational, Scientific and Cultural Organization (UNESCO).

The IUPHAR Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR, links to GtoPdb site), founded in 1987, is chaired by Michael Spedding (France) and has the mission of issuing guidelines for receptor and ion channel classification, addressing the main issues in pharmacology today, classifying the major receptor and ion channel systems, facilitating the interface between the discovery of new sequences from the Human Genome Project and the designation of the derived proteins as functional receptors and ion channels and maintaining a website (the IUPHAR/BPS Guide to PHARMACOLOGY portal) with access to data on all known receptor systems, freely available to all scientists, anywhere in the world. NC-IUPHAR publishes articles on receptor nomenclature and guidelines for terminology in Pharmacological Reviews, in collaboration with ASPET, and also publishes reviews and editorials on other topics in the British Journal of Pharmacology.

Click here for the full publication list. (links to GtoPdb site)