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This is beta-release v3.0 of the GtoImmuPdb. It contains the majority of features and functionality expected in the full public release. However, it remains under development and while it should not contain any critical bugs, some portions are not yet optimised and may lack full functionality or content. Report a bug

Targets Associated to Immuno Cell Types - Other T cells

Jump to: GPCR | Catalytic Receptors | Other Protein Targets |

The Other T cells category includes the following Cell Ontology parent terms:

gamma-delta T cell (CL:0000798) - A T cell that expresses a gamma-delta (γδ) T cell receptor complex. A major subset of human γδ T cells express Vγ2Vδ2 TCRs (also termed Vγ9Vδ2 TCRs).
memory T cell (CL:0000813) - A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.
naive T cell (CL:0000898) - Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
mucosal invariant T cell (CL:0000940) - An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule.

This should encompass natural killer T cells, mucosal associated invariant T cells & memory T cells

Targets Associated to Immuno Cell Types

  • GtoPdb receptor name: Linked to detailed view page for target. The target family is shown in brackets.
  • Cell Type Association Comments: Comments provided by GtoImmuPdb curators giving more information about why the target is associated with Other T cells.
  • Cell Ontology Associations: Specific cell ontology terms annotated against the target by GtoImmupDb curators. These help provide a higher level resolution of information exact cell types the target is involved with.
  • Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.

Full documentation can be found in the GtoImmuPdb immuno cell type data documentation (PDF).

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GPCRs
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
GPR55
(Class A Orphans)
  • gamma-delta intraepithelial T cell (CL:0000801)
 (LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
GPR55
(Class A Orphans)
  • gamma-delta intraepithelial T cell (CL:0000801)
 (LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
Catalytic Receptors
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
colony stimulating factor 1 receptor
(Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family)		 Expression down-regulated in response to HMB-PP or OKT-3 activation
    		Activation of the CSF1R induces myeloid proliferation, and in the tumour microenvironment this promotes M1 to M2 polarization and accumulation of tumour-associated macrophages (TAMs). The CSF1R is therefore being investigated as an immuno-oncology drug target [1] ...
    Other Protein Targets
    GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
    V-set immunoregulatory receptor
    (Other immune checkpoint proteins)    		 Expressed on naïve CD4+ and CD8+ T cells.
    • naive T cell (CL:0000898)
    		 V-set immunoregulatory receptor (VSIR) is commonly referred to as VISTA in the literature corpus. This is an Ig superfamily (B7 family) protein that acts as an inhibitory immune-checkpoint molecule. In common with other T cell co-inhibitory receptors (e.g. CTLA-4, PD-1, TIM3, and LAG3) it is involved in maintaining peripheral tolerance [7] ...