The Other T cells category includes the following Cell Ontology parent terms:
gamma-delta T cell (CL:0000798) - A T cell that expresses a gamma-delta (γδ) T cell receptor complex. A major subset of human γδ T cells express Vγ2Vδ2 TCRs (also termed Vγ9Vδ2 TCRs). memory T cell (CL:0000813) - A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive. naive T cell (CL:0000898) - Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low. mucosal invariant T cell (CL:0000940) - An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule.
This should encompass natural killer T cells, mucosal associated invariant T cells & memory T cells |
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GPCRs
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GtoPdb receptor name (family) |
Cell Type Association Comments |
Cell Ontology Associations |
Immunopharmacology Comments |
GPR55 (Class A Orphans) |
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- gamma-delta intraepithelial T cell (CL:0000801)
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(LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
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GPR55 (Class A Orphans) |
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- gamma-delta intraepithelial T cell (CL:0000801)
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(LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
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Catalytic Receptors
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GtoPdb receptor name (family) |
Cell Type Association Comments |
Cell Ontology Associations |
Immunopharmacology Comments |
colony stimulating factor 1 receptor (Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family) |
Expression down-regulated in response to HMB-PP or OKT-3 activation |
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Activation of the CSF1R induces myeloid proliferation, and in the tumour microenvironment this promotes M1 to M2 polarization and accumulation of tumour-associated macrophages (TAMs). The CSF1R is therefore being investigated as an immuno-oncology drug target [1] ...
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Other Protein Targets
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GtoPdb receptor name (family) |
Cell Type Association Comments |
Cell Ontology Associations |
Immunopharmacology Comments |
V-set immunoregulatory receptor (Other immune checkpoint proteins) |
Expressed on naïve CD4+ and CD8+ T cells. |
- naive T cell (CL:0000898)
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V-set immunoregulatory receptor (VSIR) is commonly referred to as VISTA in the literature corpus. This is an Ig superfamily (B7 family) protein that acts as an inhibitory immune-checkpoint molecule. In common with other T cell co-inhibitory receptors (e.g. CTLA-4, PD-1, TIM3, and LAG3) it is involved in maintaining peripheral tolerance [7] ...
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