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Targets Associated to Immuno Cell Types - Other T cells

Jump to: GPCR | Catalytic Receptors | Other Protein Targets |

The Other T cells category includes the following Cell Ontology parent terms:

gamma-delta T cell (CL:0000798) - A T cell that expresses a gamma-delta (γδ) T cell receptor complex. A major subset of human γδ T cells express Vγ2Vδ2 TCRs (also termed Vγ9Vδ2 TCRs).
memory T cell (CL:0000813) - A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.
naive T cell (CL:0000898) - Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
mucosal invariant T cell (CL:0000940) - An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restricted by the MR-1 molecule.

This should encompass natural killer T cells, mucosal associated invariant T cells & memory T cells

Targets Associated to Immuno Cell Types

  • GtoPdb receptor name: Linked to detailed view page for target. The target family is shown in brackets.
  • Cell Type Association Comments: Comments provided by GtoImmuPdb curators giving more information about why the target is associated with Other T cells.
  • Cell Ontology Associations: Specific cell ontology terms annotated against the target by GtoImmupDb curators. These help provide a higher level resolution of information exact cell types the target is involved with.
  • Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.

Full documentation can be found in the GtoImmuPdb immuno cell type data documentation (PDF).

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GPCRs
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
GPR55
(Class A Orphans)
  • gamma-delta intraepithelial T cell (CL:0000801)
 (LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
GPR55
(Class A Orphans)
  • gamma-delta intraepithelial T cell (CL:0000801)
 (LPI)-activated GPR55 has been shown to negatively regulate migration to, and accumulation of γδ T cells (a type of intraepithelial lymphocytes or IELs) in the small intestine [10] ...
Catalytic Receptors
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
colony stimulating factor 1 receptor
(Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family)		 Expression down-regulated in response to HMB-PP or OKT-3 activation
    		Activation of the CSF1R induces myeloid proliferation, and in the tumour microenvironment this promotes M1 to M2 polarization and accumulation of tumour-associated macrophages (TAMs). The CSF1R is therefore being investigated as an immuno-oncology drug target [1] ...
    Other Protein Targets
    GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
    V-set immunoregulatory receptor
    (Other immune checkpoint proteins)    		 Expressed on naïve CD4+ and CD8+ T cells.
    • naive T cell (CL:0000898)
    		 V-set immunoregulatory receptor (VSIR) is commonly referred to as VISTA in the literature corpus. This is an Ig superfamily (B7 family) protein that acts as an inhibitory immune-checkpoint molecule. In common with other T cell co-inhibitory receptors (e.g. CTLA-4, PD-1, TIM3, and LAG3) it is involved in maintaining peripheral tolerance [7] ...