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Targets Associated to Immuno Cell Types - Other T cells

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The Other T cells category includes the following Cell Ontology parent terms:

gamma-delta T cell (CL:0000798) - A T cell that expresses a gamma-delta (γδ) T cell receptor complex. A major subset of human γδ T cells express Vγ2Vδ2 TCRs (also termed Vγ9Vδ2 TCRs).
memory T cell (CL:0000813) - A distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.
naive T cell (CL:0000898) - Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.
mucosal invariant T cell (CL:0000940) - An alpha-beta T cell that is found in the lamina propria of mucosal tissues and is restrict

Catalytic Receptors
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
colony stimulating factor 1 receptor
(Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family)
Expression down-regulated in response to HMB-PP or OKT-3 activation
    Activation of the CSF1R induces myeloid proliferation, and in the tumour microenvironment this promotes M1 to M2 polarization and accumulation of tumour-associated macrophages (TAMs). The CSF1R is therefore being investigated as an immuno-oncology drug target [1] ...