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Tissue repair | ||||
![]() Targets Associated to Immuno Processes
Full documentation can be found in the GtoImmuPdb immuno cell type data documentation (PDF). ✖ |
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GPCRs | ||||
GtoPdb receptor name (family) | Process Association Comments | GO Associations | Immunopharmacology Comments | |
PAR1 (Proteinase-activated receptors) |
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PAR1 has been found to mediate the effects of neutrophil elastase (NE) on γδ T cell activation, as the PAR1 inhibitor |
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Enzymes | ||||
GtoPdb receptor name (family) | Process Association Comments | GO Associations | Immunopharmacology Comments | |
enhancer of zeste 2 polycomb repressive complex 2 subunit (2.1.1.43 Histone methyltransferases (HMTs)) |
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EZH2 is involved in hematopoietic stem cell proliferation and differentiation, thymopoiesis and lymphopoiesis, with notable participation in regulating the differentiation and function of T cells. This role suggests potential applications in immune-mediated conditions, including autoimmune disorders [18] ... | ||
Haem oxygenase 1 (Haem oxygenase) |
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Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO). Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation. HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [2] ... |
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tec protein tyrosine kinase (Tec family) |
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The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ... | ||
TXK tyrosine kinase (Tec family) |
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The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ... | ||
Other Protein Targets | ||||
GtoPdb receptor name (family) | Process Association Comments | GO Associations | Immunopharmacology Comments | |
advanced glycosylation end-product specific receptor (Immunoglobulin like domain containing proteins) |
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RAGE is a single chain, membrane bound immunoglobulin type protein [12,14,24] ... |