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Targets Associated to Immuno Processes - Tissue repair

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Tissue repair

Targets Associated to Immuno Processes

  • GtoPdb receptor name: Linked to detailed view page for target. The target family is shown in brackets.
  • Process Association Comments: Comments provided by GtoImmuPdb curators giving more information about why the target is associated with Tissue repair.
  • GO Associations: Specific, immuno-relevant Gene Ontology terms annotated against the target. These show the term, its ID and GO evidence code. GO annotations with GO 'IEA' evidence are italicized to to indicate that these are annotations applied by GO without curatorial judgement, so should be used with caution.
  • Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.

Full documentation can be found in the GtoImmuPdb immuno cell type data documentation (PDF).

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GPCRs
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
PAR1
(Proteinase-activated receptors)
  • connective tissue replacement involved in inflammatory response wound healing (GO:0002248) IDA
 PAR1 has been found to mediate the effects of neutrophil elastase (NE) on γδ T cell activation, as the PAR1 inhibitor abrogates NE (from neutrophils)-induced activation of these T cells [17] ...
Enzymes
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
enhancer of zeste 2 polycomb repressive complex 2 subunit
(2.1.1.43 Histone methyltransferases (HMTs))
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration (GO:0014834) IEA
 EZH2 is involved in hematopoietic stem cell proliferation and differentiation, thymopoiesis and lymphopoiesis, with notable participation in regulating the differentiation and function of T cells. This role suggests potential applications in immune-mediated conditions, including autoimmune disorders [18] ...
Haem oxygenase 1
(Haem oxygenase)
  • wound healing involved in inflammatory response (GO:0002246) IMP
 Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO).

Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation.

HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [2] ...
tec protein tyrosine kinase
(Tec family)
  • tissue regeneration (GO:0042246) IBA
 The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ...
TXK tyrosine kinase
(Tec family)
  • tissue regeneration (GO:0042246) IBA
 The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ...
Other Protein Targets
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
advanced glycosylation end-product specific receptor
(Immunoglobulin like domain containing proteins)
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing (GO:1904597) IEA
 RAGE is a single chain, membrane bound immunoglobulin type protein [12,14,24] ...