compound 20 [PMID: 22136433] [Ligand Id: 8156] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1945559 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Inhibition of ALK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| aurora kinase A/Aurora kinase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
| ChEMBL | Inhibition of Aurora A using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| calcium/calmodulin-dependent protein kinase II beta subunit/Calcium/calmodulin-dependent protein kinase type II subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554] | ||||||||
| ChEMBL | Inhibition of CaMK2 using ATP as substrate | B | 7.08 | pIC50 | 83 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| casein kinase 1 alpha 1/Casein kinase I isoform alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Inhibition of CK1alpha using ATP as substrate | B | 6.48 | pIC50 | 330 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of CDK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| ChEMBL | Inhibition of CDK4/D1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Inhibition of full length wild type CLK1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition by NanoBRET assay | B | 6.85 | pKi | 140 | nM | Ki | J Med Chem (2020) 63: 10224-10234 [PMID:32787076] |
| ChEMBL | Inhibition of CLK1 (unknown origin) | B | 6.85 | pKi | 140 | nM | Ki | J Med Chem (2021) 64: 1392-1422 [PMID:33528252] |
| CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
| ChEMBL | Inhibition of recombinant CLK3 (unknown origin) using Ac-ERMRPRKRQGSVdP(Sox)G-NH2 as substrate after 5 mins by Omnia Kinase Assay | B | 4.57 | pKi | 26900 | nM | Ki | J Med Chem (2020) 63: 10224-10234 [PMID:32787076] |
| EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
| ChEMBL | Inhibition of EphA4 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
| ChEMBL | Inhibition of EphB4 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| epidermal growth factor receptor/Epidermal growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of HER1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Inhibition of FGFR1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
| ChEMBL | Inhibition of FGFR2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Inhibition of FGFR3 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| ChEMBL | Inhibition of FGFR3 kinase domain using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Inhibition of FGFR4 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
| ChEMBL | Inhibition of FAK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of GSK3-beta using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Inhibition of cMET using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Insulin-like growth factor I receptor/Insulin-like growth factor 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Inhibition of IGF1R using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of Ins1R using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| ChEMBL | Inhibition of IRAK4 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Inhibition of RON using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Inhibition of MK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
| ChEMBL | Inhibition of MK5 using ATP as substrate | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| KIT proto-oncogene, receptor tyrosine kinase/Mast/stem cell growth factor receptor Kit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of cKIT using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Inhibition of ERK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| mitogen-activated protein kinase 14/Mitogen-activated protein kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of p38alpha using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279] | ||||||||
| ChEMBL | Inhibition of COT1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| tyrosine kinase 2/Non-receptor tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Inhibition of TYK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol 3-kinase catalytic subunit type 3/Phosphatidylinositol 3-kinase catalytic subunit type 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075165] [GtoPdb: 2152] [UniProtKB: Q8NEB9] | ||||||||
| ChEMBL | Inhibition of VPS34 using ATP as substrate | B | 5.04 | pIC50 | >9100 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Inhibition of PI3Kalpha using ATP as substrate | B | 5.04 | pIC50 | >9100 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| ChEMBL | Inhibition of PI3Kbeta using ATP as substrate | B | 5.07 | pIC50 | 8600 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| ChEMBL | Inhibition of PI3Kdelta using ATP as substrate | B | 5.33 | pIC50 | 4700 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| ChEMBL | Inhibition of PI3Kgamma using ATP as substrate | B | 5.51 | pIC50 | 3100 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| phosphatidylinositol 4-kinase beta/Phosphatidylinositol 4-kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8] | ||||||||
| ChEMBL | Inhibition of PI4Kbeta using ATP as substrate | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Inhibition of PDGFRalpha using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| protein kinase C alpha/Protein kinase C alpha type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibition of PKCalpha using ATP as substrate | B | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| protein kinase C theta/Protein kinase C theta type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
| ChEMBL | Inhibition of PKCtheta using ATP as substrate | B | 5.85 | pIC50 | 1400 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| ret proto-oncogene/Proto-oncogene tyrosine-protein kinase receptor Ret in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Inhibition of RET using ATP as substrate | B | 5.11 | pIC50 | 7700 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase Src in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibition of cSRC using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| AKT serine/threonine kinase 1/RAC-alpha serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of PKBalpha using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| fms related receptor tyrosine kinase 3/Receptor-type tyrosine-protein kinase FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of FLT3 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| erb-b2 receptor tyrosine kinase 2/Receptor tyrosine-protein kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Inhibition of HER2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| ChEMBL | Inhibition of HER4 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Inhibition of ROCK2 using ATP as substrate | B | 6.66 | pIC50 | 220 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | Inhibition of mTOR using ATP as substrate | B | 5.04 | pIC50 | >9100 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| protein kinase N1/Serine/threonine-protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512] | ||||||||
| ChEMBL | Inhibition of PKN1 using ATP as substrate | B | 6.51 | pIC50 | 310 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| GtoPdb | - | - | 6.51 | pIC50 | 310 | nM | IC50 | J Med Chem (2012) 55: 403-13 [PMID:22136433] |
| protein kinase N2/Serine/threonine-protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
| ChEMBL | Inhibition of PKN2 using ATP as substrate | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] | ||||||||
| ChEMBL | Inhibition of PAK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2012) 55: 403-13 [PMID:22136433] |
| ChEMBL | Inhibition of PIM1 using ATP as substrate | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| ChEMBL | Inhibition of PIM2 using ATP as substrate | B | 6.62 | pIC50 | 240 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase pim-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
| ChEMBL | Inhibition of PIM3 using ATP as substrate | B | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| GtoPdb | - | - | 7.05 | pIC50 | 90 | nM | IC50 | J Med Chem (2012) 55: 403-13 [PMID:22136433] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Inhibition of PLK1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| WNK lysine deficient protein kinase 1/Serine/threonine-protein kinase WNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075173] [GtoPdb: 2280] [UniProtKB: Q9H4A3] | ||||||||
| ChEMBL | Inhibition of WNK1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Inhibition of cABL using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| ChEMBL | Inhibition of cABL T315I mutant using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
| ChEMBL | Inhibition of CSK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Fyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Inhibition of FYN using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
| ChEMBL | Inhibition of HCK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Inhibition of JAK1 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Inhibition of JAK2 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Inhibition of JAK3 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lck in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Inhibition of LCK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Inhibition of LYN using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Inhibition of AXL using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| ChEMBL | Inhibition of SYK using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase Yes in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Inhibition of YES using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Inhibition of ZAP70 using ATP as substrate | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Inhibition of KDR using ATP as substrate | B | 5.14 | pIC50 | 7200 | nM | IC50 | J Med Chem (2012) 55: 403-413 [PMID:22136433] |
| Calmodulin-dependent kinase II in Human [GtoPdb: 1554] | ||||||||
| GtoPdb | - | - | 7.08 | pIC50 | 83 | nM | IC50 | J Med Chem (2012) 55: 403-13 [PMID:22136433] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
