Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	2382	12p13.33	WNK1	WNK lysine deficient protein kinase 1
Mouse	-	2377	6 F1	Wnk1	WNK lysine deficient protein kinase 1
Rat	-	2126	4q42	Wnk1	WNK lysine deficient protein kinase 1

Previous and Unofficial Names

hereditary sensory neuropathy, type II | Hsn2 | prkwnk1

Database Links
Alphafold	Q9H4A3 (Hs), P83741 (Mm), Q9JIH7 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL1075173 (Hs), CHEMBL2176799 (Mm)
Ensembl Gene	ENSG00000060237 (Hs), ENSMUSG00000045962 (Mm), ENSRNOG00000009956 (Rn)
Entrez Gene	65125 (Hs), 232341 (Mm), 116477 (Rn)
Human Protein Atlas	ENSG00000060237 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:65125 (Hs), mmu:232341 (Mm), rno:116477 (Rn)
OMIM	605232 (Hs)
Orphanet	ORPHA120531 (Hs)
Pharos	Q9H4A3 (Hs)
RefSeq Nucleotide	NM_001184985 (Hs), NM_198703 (Mm), NM_001002823 (Rn)
RefSeq Protein	NP_061852 (Hs), NP_941992 (Mm), NP_001002823 (Rn)
UniProtKB	Q9H4A3 (Hs), P83741 (Mm), Q9JIH7 (Rn)
Wikipedia	WNK1 (Hs)

Selected 3D Structures
	Description:  Crystal structure of the kinase domain of WNK1. PDB Id:  3FPQ Resolution:  1.8Å Species:  Rat References:  1

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference PP1 Hs Inhibition 4.9 pKi 2 ⤷ pKi 4.9 (Ki 1.27x10-5 M) [2]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Neuropathy, hereditary sensory and autonomic, type IIA; HSAN2A Synonyms: Hereditary sensory and autonomic neuropathy [Disease Ontology: DOID:11533] Hereditary sensory and autonomic neuropathy type 2 [Orphanet: ORPHA970] Disease Ontology: DOID:11533 OMIM: 201300 Orphanet: ORPHA970
Disease:  Pseudohypoaldosteronism, type IIC; PHA2C Synonyms: Pseudohypoaldosteronism [Disease Ontology: DOID:4479] Pseudohypoaldosteronism type 2C [Orphanet: ORPHA88940] Disease Ontology: DOID:4479 OMIM: 614492 Orphanet: ORPHA88940