The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

GtoImmuPdb ligands only: Ligands which are currently, or have been in the past, approved for human clinical use by a regulatory agency.

A  B  C  D  E  F  G  H  I  K  L  M  N  O  P  R  S  T  U  V  Z 

Ligand name ID Synonyms
A Back to top
abatacept 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
ACTH  {Sp: Human} 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
adalimumab 4860 D2E7, FKB327, Humira®
(-)-adrenaline 479 adrenalin, Auvi-Q®, Epipen®, l-adrenaline, L-epinephrine, levoepinephrine
alcaftadine 7587 Lastacaft®, R-89674
alefacept 6787 Amevive®, BG 9273, BG 9712, BG-9273, BG-9712, Lfa3Tip
alemtuzumab 6770 campath 1H, Campath®, campath-1H, Lemtrada®
alimemazine 7237 Nedeltran®, trimeprazine
amcinonide 7060 CL-34699, Cyclocort®
amlexanox 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
anakinra 6972 antril, Kineret®
apremilast 7372 CC-10004, Otezla®
arformoterol 7479 Brovana®, YM-08316
aspirin 4139 Acetophen®, acetylsalicylic acid, Aspirin®
atezolizumab 7990 MPDL3280A, Tecentriq®
atracurium 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
auranofin 6306 Ridaura®, SK&F-39162, SK-39162
avelumab 8735 Bavencio®, MSB-0010718C, MSB0010718C
azacitidine 6796 5-AZAC, 5-azacytidine, ladakamycin, U-18496, Vidaza®
azatadine 7119 Optimine®, SCH-10649
azathioprine 7120 Azasan®, BW-57-322, Imuran®
azelaic acid 7484 Azelex®, Finacea®, ZK-62498
 
B Back to top
basiliximab 6879 CHI-621, L04AC02, SDZ-CHI-621, Simulect®
beclometasone 7059 beclomethasone, SCH-18020W
beclometasone dipropionate 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
belatacept 6892 BMS-224818, LEA29Y, Nulojix®
belimumab 6887 Benlysta®, hBlySmAb-1.1, lymphostat-B
betamethasone 7061 SCH-4831
blinatumomab 7384 Blincyto®, bscCD19xCD3, MEDI-538, MT-103, MT103
bosutinib 5710 Bosulif®, SK 606, SK-606, SKI 606
brentuximab vedotin 6772 Adcetris®, anti-CD30 ADC SGN-35, SGN 35
brodalumab 7540 AMG-827, AMG827, Lumicef®, Siliq®
bromfenac 7131 AHR-10282B, Bromday®, Prolensa®, Xibrom®
budesonide 7434 Entocort®, Pulmicort®, S-1320, Uceris®
 
C Back to top
canakinumab 6773 ACZ 885, ACZ885, Ilaris®
carprofen 7141 Ro-205720000
celecoxib 2892 Celecox®, Onsenal®
certolizumab pegol 6774 CDP870, Cimzia®, PHA 738144
cetirizine 1222 Reactine®, Zyrtec®
ciclesonide 7469 Alvesco®, Omnaris®, RPR-251526
clemastine 6063 HS-592, meclastin, Tavegil®, Tavist®
clobetasol propionate 7062 CCI-4725, Clobex®, Dermovate®, GR 2/925, Temovate®
clobetasone 9088 Eumovate®
clofazimine 9184 Lamprene®
corticotropin zinc hydroxide 6967
cortisol 2868 Acticort®, Plenadren®
crisaborole 9151 AN 2728, AN2728, compound 5b [PMID: 19303290], Eucrisa®
cromoglicic acid 7608 cromoglycate, cromolyn, cromolyn sodium, FPL-670, Intal®, Opticrom®, sodium cromoglicate
cyclosporin A 1024 ciclosporin, cyclosporine, cyclosporine A, Neoral®, Sandimmune®
 
D Back to top
daclizumab 6880 L04AC01, RO-24-7375, Ro-247375, Zenapax®
daratumumab 7395 3003-005, Darzalex®, HuMax-CD38, JNJ-54767414
dasatinib 5678 BMS 345825, BMS 354825, BMS 35482513, Sprycel®
deflazacort 9477 Emflaza®, MDL 458
denileukin diftitox 7044 DAB389 IL2, LY 335348, Ontak®
desloratadine 7157 Clarinex®, SCH-34117
desonide 7066 D-2083, Desowen®
desoximetasone 7067 A-41-304, HOE-304, R-2113, Topicort®
dexamethasone 2768 Decadron®, desametasone, fluormethylprednisolone
diclofenac 2714 Cataflam®, CGP-45840B, GP-45840, Voltaren®, Voltarol®
diflorasone diacetate 7068 Psorcon®, U-34865
diflunisal 7162 Dolobid®
difluprednate 7474 DFBA, Durezol®, W-6309
diphenylpyraline 7165 Hispril®
dupilumab 7574 Dupixent®, REGN668, SAR231893
dyphylline 7070 Dilor®
 
E Back to top
ecallantide 6955 DX-88, FOV2302, Kalbitor®
eculizumab 6884 h5G1.1, h5G1.1VHC, Soliris®
efalizumab 6593 anti alphaL integrin, antiCD11 alpha, hu1124, Raptiva®
elotuzumab 8361 BMS-901608, Empliciti®, HuLuc63
esflurbiprofen 9420 (S)-flurbiprofen, BTS-24332, SFPP, TT-063
etanercept 6789 Enbrel®, Rhu Tnfr:Fc, TNFR-Fc, TNR 001
etodolac 7185 AY-24236, Lodine®
etoricoxib 2896 Arcoxia®, MK 0663, MK-0663
 
F Back to top
fenoprofen 4820 fenoprofen calcium, Nalfon®
fexofenadine 4819 Allegra®, fexofenadine HCl
filgrastim 6968 Filcad®, Imumax ®, R-METHUG-CSF
fingolimod 2407 FTY-720, FTY720, Gilenya®
fludroxycortide 7606 Cordran®, flurandrenolide, flurandrenolone, Haelan®
flumethasone pivalate 7075 Locorten®
flunisolide 7076 AeroBid®, RS-3999
fluocinolone acetonide 7077 Capex®, Iluvien®, Synalar®
fluocinonide 7078 Fluonex®, Lidex®
fluorometholone 7079 Flarex®, FML®
flurbiprofen 4194 Ansaid®, Froben®
fluticasone 6699 Advair®, Flovent HFA®, Veramyst®
fluticasone propionate 7080 Advair Diskus®, ArmonAir RespiClickTM, CCI-18781, Flovent®
formoterol 3465 BD-40A, CGP-25827A, Foradil®, Oxeze/Oxis®, YM-08316
 
G Back to top
G-CSF  {Sp: Human} 4934 Granocyte®
gemtuzumab ozogamicin 6775 CDP 771, CMA 676, hP67.6-calicheamicin, Mylotarg®, WAY-CMA 676
glycopyrrolate 7459 AHR-504, Robinul®, Seebri Neohaler®
golimumab 6776 CNTO-148, CNTO148, Simponi®
 
H Back to top
hydroxyzine 7199 Atarax®, hydroxyzine hydrochloride, hydroxyzine pamoate, Vistaril®
 
I Back to top
ibritumomab tiuxetan 6777 IDEC-2B8, IDEC-Y2B8-yttrium ibritumomab tiuxetan, NSC-715848, Zevalin®
ibrutinib 6912 Imbruvica®, PCI-32765
ibuprofen 2713 Advil®, Brufen®, ibuprofen lysine, ibuprofen sodium, Motrin®, Nurofen®, U-18573
icatibant 667 D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]BK, Firazyr®, HOE 140, HOE140
idelalisib 6741 CAL-101/CAL101, GS-1101, Zydelig®
IFN-α2  {Sp: Human} 4960 IFN-alpha-2, interferon alpha-2, Roferon A®
IFN-γ  {Sp: Human} 4968 Actimmune®, immune interferon, interferon gamma
IFN-β1b (recombinant human) 8340 Betaferon®, Betaseron®, Extavia®, IFNb1b
IL-2  {Sp: Human} 4985 aldesleukin, interleukin-2, Proleukin®
iloprost 1895 Ventavis®
imatinib 5687 CGP 57148, Gleevec®, Glivec®, STI571
imiquimod 5003 Aldara®, R837, S-26308, Zyclara®
indacaterol 7455 Arcapta Neohaler®, Onbrez®, QAB-149, QAB149
indomethacin 1909 Indocid®, Indocin®
infliximab 5004 cA2, Inflectra®, Remicade®, Remsima®, SB2, TA-650
ipilimumab 6888 MDX-010, MDX-101, MDX-CTLA-4, Yervoy®
ipratropium 325 Atrovent®, Ipraxa®
isoetarine 7205 Bronkometer®, Bronkosol®, WIN-3406
itolizumab 9421 Alzumab®, T1h
ixekizumab 7541 LY-2439821, Taltz®
 
K Back to top
ketoprofen 4795 Actron®, Orudis®
ketorolac 6661 Acular®, Toradol®
 
L Back to top
leflunomide 6825 Arabloc®, Arava®, HWA 486, HWA-486, lefunamide, SU-101
lifitegrast 7533 compound 1g [PMID: 24900456], SAR 1118, SAR-1118, SAR-1118-023, Xiidra®
loratadine 7216 Claritin®, SCH-29851
loteprednol etabonate 7085 HGP-1, Lotemax®, P-5604
lumiracoxib 2897 Prexige®
 
M Back to top
maraviroc 806 Celsentri®, Selzentry®, UK 427857, UK-427,857
meclofenamic acid 7219 CL-583, INF-4668, Meclomen®
medrysone 7086 U-8471
mefenamic acid 2593 CI-473, CN-35355, INF-3355, Ponstan®, Ponstel®
meloxicam 7220 Mobic®, UHAC-62XX
mepolizumab 7685 Nucala®, SB-240563
methacholine 7438 methacholine bromide, Provocholine®
methimazole 6649 Tapazole®, Thiamazole®
methotrexate 4815 Abitrexate®, amethopterin, Rasuvo®
methylprednisolone 7088 Medrol®, U-67590A
midostaurin 5702 CGP 41231, CGP 41251, N-benzoylstaurosporine, PKC412, Rydapt®
mifepristone 2805 Mifeprex®, RU-486, RU486
mogamulizumab 6477 KW-0761, Poteligeo®
mometasone 9029 Elocon® (topical), Nasonex®
montelukast 3340 Singulair®
muromonab-CD3 6889 L04AA02, OKT-3, Orthoclone Okt3®
 
N Back to top
nabumetone 7245 BRL-14777, Relafen®
naproxen 5230 (S)-naproxen, Aleve®, Naprosy®
natalizumab 6591 AN100226, anti-alpha4 integrin, anti-VLA4, Tysabri®
nedocromil 7607 FPL-59002, nedocromil sodium, Rapitil®, Tilade®
niflumic acid 2439
nimesulide 7401 R-805
nivolumab 7335 BMS-936558, MDX-1106, ONO-4538, Opdivo®
 
O Back to top
obinutuzumab 6941 GA-101, GA101, Gazyva®
ocrelizumab 7580 2H7, Ocrevus®, PRO70769, RG1594
ofatumumab 6778 Arzerra®, GSK 1841157, GSK1841157, humax-CD20
olodaterol 7543 BI-1744, BI-1744-CL, Striverdi®
omalizumab 6890 IGE25, olizumab, R03DX05, RG-3648, rhumab-E25, Xolair®
oprelvekin 6971 Neumega®
oxaprozin 7252 Daypro®, WY-21743
 
P Back to top
peginterferon alfa-2b 7462 PegIntron®, Sylatron®
peginterferon beta-1a 7637 interferon beta 1-alpha, PEG-INF-β-1a, Plegridy®
pembrolizumab 7499 Keytruda®, lambrolizumab, MK-3475
penicillamine 7264 Cuprimine®
PGE2 1883 Cervidil®, minprositin E2, minprostin E2, Propess®, prostaglandin E2
phenylbutazone 7270 Butazolidine®
pirfenidone 7532 AMR-69, Esbriet®
piroxicam 7273 CP-16171, Feldene®
plerixafor 844 AMD 3100, AMD3100, bicyclam JM-2987, JM 3100, Mozobil®
polmacoxib 8316 Acelex® (S. Korea), CG-100649, CG100649
prednicarbate 7605 Dermatop®, Hoe 777, Hoe-777, S-770777
prednisolone 2866 DELTA.1-Cortisol, Orapred®, Pediapred®
prednisone 7096 Lodotra®, Sterapred®
procaterol 3464
 
R Back to top
reslizumab 8091 CDP-835, CDP835, Cinqair®, JES1-39D10, SCH55700
rilonacept 6790 Arcalyst®, IL-1 Trap, interleukin-1 Trap
rimexolone 7099 ORG-6216, Vexol®
rituximab 6780 HSDB 7455, MabThera®, Rituxan®
rofecoxib 2893 Ceoxx®, MK 966, Vioxx®
roflumilast 6962 BY-217, BYK-20869, Daliresp®, Daxas®
ruxolitinib 5688 (R)-ruxolitinib, INC424, INCB 18424, INCB018424, Jakafi®, Jakavi®
 
S Back to top
salbutamol 558 albuterol, SCH-13949W, Ventolin®
salicylic acid 4306 Bazuka Extra Strength Gel®, salicylate
salmeterol 559 GR 33343X, Serevent®
secukinumab 8078 AIN 457, AIN457, Cosentyx®, NVP-AIN457
siltuximab 7396 cLLB8, CNTO 328, Sylvant®
sirolimus 6031 AY-22989, Rapamune®, rapamycin, WY-090217
sulindac 5425 Clinoril®
suprofen 7298 Profenal®, R-25061
 
T Back to top
telotristat ethyl 9490 LX-1606, LX1606, Xermelo®
teriflunomide 6844 A77 1726, Aubagio®, flucyamide, HMR-1726
thalidomide 7327 K-17
theophylline 413 Nuelin®, Slo-Bid®, Theolair®
tiotropium 367 BA-679-BR, Spiriva®
tocilizumab 6881 Actemra®, R-1569, RG-1569, RHPM-1, RoActemra®
tofacitinib 5677 CP-690,550, CP-690550, tasocitinib, Xeljanz®
tolmetin 7311 MCN-2559, McN-2559-21-98, Tolectin®
tositumomab 6781 Bexxar®, V10XA53
tranilast 6326 MK-341, SB-252218
triamcinolone 2870 fluoxiprednisolone, Kenalog®, Nasacort®
tripelennamine 7318 Pyribenzamine®
 
U Back to top
umeclidinium 7354 Incruse Ellipta®
ustekinumab 6885 CNTO-1275, L04AC05, Stelara®, TT-20
 
V Back to top
valdecoxib 2894 Bextra®, SC-65872
vedolizumab 7437 Entyvio®, LDP-02, LDP02, MLN-0002, MLN-002, MLN002
venetoclax 8318 ABT-199, GDC-0199, Venclexta TM
vilanterol 7353 GW642444X
 
Z Back to top
zafirlukast 3322 Accolate®, ICI-204219
zileuton 5297 A-64077, ZYFLO®