imiquimod   Click here for help

GtoPdb Ligand ID: 5003

Synonyms: Aldara® | R837 | S-26308 | Zyclara®
Approved drug PDB Ligand Immunopharmacology Ligand
imiquimod is an approved drug (FDA (1997), EMA (1998))
Compound class: Synthetic organic
Comment: Imiquimod is a TLR7 agonist acting as an immunomodulator.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 56.73
Molecular weight 240.14
XLogP 2.71
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC(Cn1cnc2c1c1ccccc1nc2N)C
Isomeric SMILES CC(Cn1cnc2c1c1ccccc1nc2N)C
InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChI Key DOUYETYNHWVLEO-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1997), EMA (1998))
IUPAC Name Click here for help
1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
International Nonproprietary Names Click here for help
INN number INN
6911 imiquimod
Synonyms Click here for help
Aldara® | R837 | S-26308 | Zyclara®
Database Links Click here for help
CAS Registry No. 99011-02-6
ChEBI CHEBI:36704
ChEMBL Ligand CHEMBL1282
DrugBank Ligand DB00724
DrugCentral Ligand 1429
GtoPdb PubChem SID 178101700
PubChem CID 57469
RCSB PDB Ligand 6T0
Search Google for chemical match using the InChIKey DOUYETYNHWVLEO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DOUYETYNHWVLEO
Search PubMed clinical trials imiquimod
Search PubMed titles imiquimod
Search PubMed titles/abstracts imiquimod
UniChem Compound Search for chemical match using the InChIKey DOUYETYNHWVLEO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey DOUYETYNHWVLEO-UHFFFAOYSA-N
Wikipedia Imiquimod

Product suppliers

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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Tocris
Imiquimod (links to external site)
Cat. No. 3700