dimetindene

Ligand id: 10101

Name: dimetindene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 16.13
Molecular weight 292.19
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name
N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
International Nonproprietary Names
INN number INN
1403 dimetindene
Synonyms
(+/-)-dimethindene | dimethindene | dimethpyrindene | Fenistil® | Vibrocil®
Comments
Dimetindene is an orally active, selective histamine H1 receptor antagonist. It also has anticholinergic activity [1]. The INN specifies the racemic mixture of (R)- and (S)-enantiomers. We show the structure without specified stereochemistry to represent that mixture.
Database Links
BindingDB Ligand 81452
CAS Registry No. 5636-83-9 (source: PubChem)
ChEMBL Ligand CHEMBL22108
GtoPdb PubChem SID 381118811
PubChem CID 21855
Search Google for chemical match using the InChIKey MVMQESMQSYOVGV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone MVMQESMQSYOVGV
Search PubMed clinical trials dimetindene
Search PubMed titles dimetindene
Search PubMed titles/abstracts dimetindene
Search UniChem for chemical match using the InChIKey MVMQESMQSYOVGV-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone MVMQESMQSYOVGV