mizolastine

Ligand id: 10102

Name: mizolastine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 70.05
Molecular weight 432.21
XLogP 5.36
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (UK (2003))
International Nonproprietary Names
INN number INN
6663 mizolastine
Synonyms
Mizollen® | MKC-431 | MKC431 | SL 85.0324 [1] | SL-850324 | SL850324
Comments
Mizolastine is a highly selective, long-acting second generation histamine H1 receptor antagonist [1] that is used clinically as an antiallergy medication. It does not cross the blood-brain barrier and does not bind the muscarinic cholinergic M1 receptor [2].
Database Links
BindingDB Ligand 22877
CAS Registry No. 108612-45-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL94454
GtoPdb PubChem SID 381118812
PubChem CID 65906
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