desloratadine   Click here for help

GtoPdb Ligand ID: 7157

Synonyms: Clarinex® | SCH-34117
Approved drug PDB Ligand Immunopharmacology Ligand
desloratadine is an approved drug (FDA and EMA (2001))
Compound class: Synthetic organic
Comment: Desloratadine is a tricyclic H1-antihistamine. It is the major metabolite of loratadine.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: desloratadine

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 24.92
Molecular weight 310.12
XLogP 3.19
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1
Isomeric SMILES Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1
InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI Key JAUOIFJMECXRGI-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA and EMA (2001))
IUPAC Name Click here for help
8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,4-b]pyridine
International Nonproprietary Names Click here for help
INN number INN
7817 desloratadine
Synonyms Click here for help
Clarinex® | SCH-34117
Database Links Click here for help
Specialist databases
GPCRdb Ligand desloratadine
Other databases
CAS Registry No. 100643-71-8
ChEMBL Ligand CHEMBL1172
DrugBank Ligand DB00967
DrugCentral Ligand 814
GtoPdb PubChem SID 178103732
PubChem CID 124087
RCSB PDB Ligand Y5R
Search Google for chemical match using the InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JAUOIFJMECXRGI
Search PubMed clinical trials desloratadine
Search PubMed titles desloratadine
Search PubMed titles/abstracts desloratadine
UniChem Compound Search for chemical match using the InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N
Wikipedia Desloratadine

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Tocris
Desloratadine (links to external site)
Cat. No. 5958