miltefosine [Ligand Id: 11355] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL125 (D-18506, HDPC, Impavido, Miltefosine, Miltex, NSC-605583, NSC-758968) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304] | ||||||||
| ChEMBL | Inhibition of Cell division cycle 25 (Cdc25) phosphatase | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1996) 39: 2609-2614 [PMID:8691459] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG incubated for 2 hrs by fluorescence polarisation assay | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2018) 146: 423-434 [PMID:29407968] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of Akt phosphorylation in human insulin-stimulated A549 cells incubated for 2 hrs prior to insulin-induction measured after 30 mins by ELISA | B | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2013) 21: 2018-2024 [PMID:23415083] |
| GtoPdb | Measuring inhibition of AKT1 phosphorylation in A549 human epithelial lung cancer cells. | - | 5.02 | pIC50 | 9600 | nM | IC50 | Bioorg Med Chem (2013) 21: 2018-24 [PMID:23415083] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
