SU11274

Ligand id: 5057

Name: SU11274

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 114.2
Molecular weight 567.17
XLogP 3.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
MET proto-oncogene, receptor tyrosine kinase Met/c-MET Hs Inhibitor Inhibition 1.2 2.0 0.0
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 5.1 7.0 2.0
mitogen-activated protein kinase kinase kinase kinase 5 nd/KHS(MAP4K5) Hs Inhibitor Inhibition 5.1
unc-51 like autophagy activating kinase 1 nd/ULK1 Hs Inhibitor Inhibition 5.2
neurotrophic receptor tyrosine kinase 3 nd/TRKC Hs Inhibitor Inhibition 5.9
leucine rich repeat kinase 2 nd/LRRK2 Hs Inhibitor Inhibition 6.6
neurotrophic receptor tyrosine kinase 1 TrkA/TRKA Hs Inhibitor Inhibition 7.8 0.0 2.0
serine/threonine kinase 10 LOK/LOK(STK10) Hs Inhibitor Inhibition 9.1 13.0 10.0
STE20 like kinase nd/SLK(STK2) Hs Inhibitor Inhibition 13.6
NUAK family kinase 1 ARK5/ARK5(NUAK1) Hs Inhibitor Inhibition 15.9 30.0 27.0
Displaying the top 10 targets  View all targets in screen »