Synonyms: Met kinase Inhibitor | SU-11274
Compound class:
Synthetic organic
Comment: SU11274 is a selective Met inhibitor [6].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377] |
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362] |
3. Haddad R, Lipson KE, Webb CP. (2001)
Hepatocyte growth factor expression in human cancer and therapy with specific inhibitors. Anticancer Res, 21 (6B): 4243-52. [PMID:11908677] |
4. Longati P, Comoglio PM, Bardelli A. (2001)
Receptor tyrosine kinases as therapeutic targets: the model of the MET oncogene. Curr Drug Targets, 2 (1): 41-55. [PMID:11465538] |
5. Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R. (2002)
Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition. Cytokine Growth Factor Rev, 13 (1): 41-59. [PMID:11750879] |
6. Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S et al.. (2003)
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion. Mol Cancer Ther, 2 (11): 1085-92. [PMID:14617781] |