SU11274

Ligand id: 5057

Name: SU11274

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 114.2
Molecular weight 567.17
XLogP 3.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
Activation of Met by HGF induces many cellular responses, including proliferation, survival, motility, invasion, and morphological changes [3,5]. Abberant Met activity is associated with tumourigenicity and metastatic potential of tumour cells. Met inhiition aims to reduce the abberant Met activity and thereby slow tumour growth and/or metastasis [4].