Ligand id: 5057

Name: SU11274

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 114.2
Molecular weight 567.17
XLogP 3.74
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
SU11274 inhibits HGF-induced motility and invasion of epithelial and carcinoma cells [6]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 8.0 pIC50 - 6
pIC50 8.0 (IC50 1x10-8 M) [6]
Description: Assay used a GST fusion with the cytoplasmic domain of human Met.
Ligand mentioned in the following text fields