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C-type lectin domain family 4 member C

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Immunopharmacology Ligand  Target has curated data in GtoImmuPdb

Target id: 3135

Nomenclature: C-type lectin domain family 4 member C

Abbreviated Name: BDCA2

Family: C-type lectin-like receptors (CLRs)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 213 12p13.31 CLEC4C C-type lectin domain family 4 member C
Mouse 1 209 6 F2 Clec4b1 C-type lectin domain family 4, member b1
Rat 1 208 4q42 Clec4b2 C-type lectin domain family 4, member B2
Previous and Unofficial Names Click here for help
C-type lectin domain family 4, member B2 | C-type lectin domain family 4 | C-type lectin domain family 4, member b1 | BDCA2 | Blood dendritic cell antigen 2 | CD303 | Dendritic lectin | DLEC | BDCA-2
Database Links Click here for help
Alphafold Q8WTT0 (Hs)
ChEMBL Target CHEMBL2176855 (Hs)
Ensembl Gene ENSG00000198178 (Hs), ENSMUSG00000030147 (Mm), ENSRNOG00000027655 (Rn)
Entrez Gene 170482 (Hs), 69810 (Mm)
Human Protein Atlas ENSG00000198178 (Hs)
KEGG Gene hsa:170482 (Hs), mmu:69810 (Mm)
OMIM 606677 (Hs)
Pharos Q8WTT0 (Hs)
RefSeq Nucleotide NM_130441 (Hs), NM_001190310 (Mm), NM_001005896 (Rn)
RefSeq Protein NP_569708 (Hs), NP_001177239 (Mm), NP_001005896 (Rn)
UniProtKB Q8WTT0 (Hs)
Wikipedia CLEC4C (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
litifilimab Peptide Immunopharmacology Ligand Hs Binding - - 2
⤷ [2]
Immunopharmacology Comments
CLEC4C (BDCA2) is a type 2 transmembrane protein that is selectively expressed by plasmacytoid dendritic cells (pDCs). Like other C-type lectins, this membrane protein has roles in inflammation and immune responses. It is reported to capture non-sialylated galactose-terminated complex glycan antigens [4] and present them to T cells [1]. Ligand binding to CLEC4C inhibits induction of interferon (IFN) α/β production in pDCs. Since pDC-derived IFN α/β is considered to be a major pathophysiological driver in systemic lupus erythematosus (SLE), CLEC4C is being investigated as molecular target for the treatment of autoimmune lupus diseases, both SLE and the cutaneous form [2].
Cell Type Associations
Immuno Cell Type:  Dendritic cells
Cell Ontology Term:   plasmacytoid dendritic cell (CL:0000784)
References:  3
General Comments
CLEC4C is an immunoreceptor that expressed exclusively by plasmacytoid dendritic cells (pDCs).

References

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1. Dzionek A, Sohma Y, Nagafune J, Cella M, Colonna M, Facchetti F, Günther G, Johnston I, Lanzavecchia A, Nagasaka T et al.. (2001) BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. J Exp Med, 194 (12): 1823-34. [PMID:11748283]

2. Furie R, Werth VP, Merola JF, Stevenson L, Reynolds TL, Naik H, Wang W, Christmann R, Gardet A, Pellerin A et al.. (2019) Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus. J Clin Invest, 129 (3): 1359-1371. [PMID:30645203]

3. Murray L, Xi Y, Upham JW. (2019) CLEC4C gene expression can be used to quantify circulating plasmacytoid dendritic cells. J Immunol Methods, 464: 126-130. [PMID:30395816]

4. Riboldi E, Daniele R, Parola C, Inforzato A, Arnold PL, Bosisio D, Fremont DH, Bastone A, Colonna M, Sozzani S. (2011) Human C-type lectin domain family 4, member C (CLEC4C/BDCA-2/CD303) is a receptor for asialo-galactosyl-oligosaccharides. J Biol Chem, 286 (41): 35329-33. [PMID:21880719]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member C. Last modified on 16/07/2020. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3135.