Synonyms: C-176 STING inhibitor
Compound class:
Synthetic organic
Comment: A covalent inhibitor of mouse stimulator of interferon genes (mSTING) protein, with no effect on the human protein [1]. C-176 binding blocks activation-induced palmitoylation of mSTING and clustering of STING that plays a part in promoting downstream inflammatory signalling.
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References |
1. Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R et al.. (2018)
Targeting STING with covalent small-molecule inhibitors. Nature, 559 (7713): 269-273. [PMID:29973723] |