Synonyms: C-176 STING inhibitor
Compound class:
Synthetic organic
Comment: A covalent inhibitor of mouse stimulator of interferon genes (mSTING) protein, with no effect on the human protein [1]. C-176 binding blocks activation-induced palmitoylation of mSTING and clustering of STING that plays a part in promoting downstream inflammatory signalling.
|
|
Immunopharmacology Comments |
Can be used in experimental models to inhibit STING-mediated inflammatory cytokine production. |