Synonyms: C-176 STING inhibitor
Compound class:
Synthetic organic
Comment: A covalent inhibitor of mouse stimulator of interferon genes (mSTING) protein, with no effect on the human protein [1]. C-176 binding blocks activation-induced palmitoylation of mSTING and clustering of STING that plays a part in promoting downstream inflammatory signalling.
|
|
Bioactivity Comments |
Reduces pathological pro-inflammatory mediator production in autoinflammatory disease models [1]. |