Synonyms: AZD-4721 | AZD4721 | compound 4 [WO2019055509A1] | RIST4721
Compound class:
Synthetic organic
Comment: Vimnerixin (AZD4721/RIST4721 ) is an orally bioavailable CXC chemokine receptor type 2 antagonist [1]. It has minimal activity on CXCR1, so has little effect on neutrophil activation.
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References |
1. Bissonnette R, Maari C, Tsianakas A, Reid D, McCutchan S, Baumgartner S, Mackay J, Bhakta N. (2021)
A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis. Dermatol Ther (Heidelb), 11 (6): 2179-2193. [PMID:34716902] |