Synonyms: AZD-4721 | AZD4721 | compound 4 [WO2019055509A1] | RIST4721
Compound class:
Synthetic organic
Comment: Vimnerixin (AZD4721/RIST4721 ) is an orally bioavailable CXC chemokine receptor type 2 antagonist [1]. It has minimal activity on CXCR1, so has little effect on neutrophil activation.
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Immunopharmacology Comments |
CXCR2 is important for neutrophil recruitment and migration. Antagonising its activation by endogenous ligands such as IL-8, induces an anti-inflammatory effect, that would be useful for treating neutrophil-mediated inflammatory disorders. |