Compound class:
Synthetic organic
Comment: 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite produced by platelets and mast cells) is reported to act via GPR35 as a neutrophil chemoattractant that recruits neutrophils to sites of inflammation [1].
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References |
1. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. (2022)
GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell, 185 (5): 815-830.e19. [PMID:35148838] |