Compound class:
Synthetic organic
Comment: 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite produced by platelets and mast cells) is reported to act via GPR35 as a neutrophil chemoattractant that recruits neutrophils to sites of inflammation [1].
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Bioactivity Comments |
Direct binding of 5-HIAA to GPR35 has not been demonstrated, but evidence from functional studies indirectly suggests that 5-HIAA is acting via this orphan GPCR [1]. |