Compound class:
Synthetic organic
Comment: 5-hydroxyindoleacetic acid (5-HIAA; a serotonin metabolite produced by platelets and mast cells) is reported to act via GPR35 as a neutrophil chemoattractant that recruits neutrophils to sites of inflammation [1].
|
|
Immunopharmacology Comments |
5-HIAA from platelets and mast cells can act as a chemoattractant that recruits neutrophils to the site of inflammation. This activity seems to rely on the participation of the orphan GPCR, GPR35. |