ChEMBL ligand: CHEMBL71 (Aminazine, Chlorpromazine, Chlorpromazine hibenzate, Chlorpromazine phenolphthalinate, Chlorpromazine tannate, Chlorpromazinum, Elmarin, Esmind, Fenactil, J2.794D, Largactil, Largactilothiazine, Megaphen, Novomazina, NSC-167745, NSC-226514, Propaphenin, Sanopron, SKF-2601A, Sonazine, Thorazine, Wintermin)
Acetylcholine receptor protein alpha chain in Torpedo californica [ChEMBL: CHEMBL3097] [UniProtKB: P02710] There should be some charts here, you may need to enable JavaScript!
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] There should be some charts here, you may need to enable JavaScript!
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] There should be some charts here, you may need to enable JavaScript!
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
ABCB11/Bile salt export pump in Human [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342] There should be some charts here, you may need to enable JavaScript!
Calmodulin in Human [ChEMBL: CHEMBL6093] [UniProtKB: P0DP23] Calmodulin in Bovine [ChEMBL: CHEMBL6092] [UniProtKB: P62157] There should be some charts here, you may need to enable JavaScript!
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] D1 receptor/Dopamine D1 receptor in Rat [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] Dopamine D2 receptor in Bovine [ChEMBL: CHEMBL3998] [UniProtKB: P20288] D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] Histamine H1 receptor in Guinea pig [ChEMBL: CHEMBL3943] [UniProtKB: P31389] There should be some charts here, you may need to enable JavaScript!
H2 receptor/Histamine H2 receptor in Human [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021] There should be some charts here, you may need to enable JavaScript!
H3 receptor/Histamine H3 receptor in Human [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
MC3 receptor/Melanocortin receptor 3 in Human [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968] There should be some charts here, you may need to enable JavaScript!
MC4 receptor/Melanocortin receptor 4 in Human [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245] There should be some charts here, you may need to enable JavaScript!
MC5 receptor/Melanocortin receptor 5 in Human [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
M3 receptor/Muscarinic acetylcholine receptor M3 in Human [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] There should be some charts here, you may need to enable JavaScript!
M4 receptor/Muscarinic acetylcholine receptor M4 in Human [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] There should be some charts here, you may need to enable JavaScript!
M5 receptor/Muscarinic acetylcholine receptor M5 in Human [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] There should be some charts here, you may need to enable JavaScript!
NK2 receptor/Neurokinin 2 receptor in Human [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL1697658] [UniProtKB: P33302] There should be some charts here, you may need to enable JavaScript!
K2P2.1/Potassium channel subfamily K member 2 in Human [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069] There should be some charts here, you may need to enable JavaScript!
Prion protein in Human [ChEMBL: CHEMBL4869] [UniProtKB: P04156] Prion protein in Mouse [ChEMBL: CHEMBL3698] [UniProtKB: P04925] There should be some charts here, you may need to enable JavaScript!
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] There should be some charts here, you may need to enable JavaScript!
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit [ChEMBL: CHEMBL4693] [UniProtKB: P04191] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405] There should be some charts here, you may need to enable JavaScript!
Trypanothione reductase in Trypanosoma cruzi [ChEMBL: CHEMBL5131] [UniProtKB: P28593] There should be some charts here, you may need to enable JavaScript!
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Rat [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acetylcholine receptor protein alpha chain in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097] [UniProtKB: P02710]
ChEMBL	Displacement of [3H]PCP from nAChR in Torpedo nobiliana electric organs membranes by scintillation counting method	B	4.79	pIC50	16400	nM	IC50	J Pestic Sci (1995) 20: 49-56
ChEMBL	Displacement of [3H]PCP from nAChR in Torpedo nobiliana electric organs membranes in presence of 100 uM carbachol by scintillation counting method	B	5.89	pIC50	1280	nM	IC50	J Pestic Sci (1995) 20: 49-56
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	8.46	pKi	3.46	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	8.07	pIC50	8.54	nM	IC50	DrugMatrix in vitro pharmacology data
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	8.3	pKi	4.96	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin)	B	8.05	pIC50	8.97	nM	IC50	DrugMatrix in vitro pharmacology data
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	8.71	pKi	1.96	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)	B	8.4	pIC50	3.99	nM	IC50	DrugMatrix in vitro pharmacology data
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
GtoPdb	-	-	6.6	pKi	-	-	-	Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	6.88	pKi	132	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912)	B	6.45	pIC50	352	nM	IC50	DrugMatrix in vitro pharmacology data
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	7.92	pKi	12	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	8.3	pKi	-	-	-	Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	7.59	pIC50	26	nM	IC50	DrugMatrix in vitro pharmacology data
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	7.27	pKi	54	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.4	pKi	-	-	-	Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
ChEMBL	DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)	B	6.43	pIC50	374	nM	IC50	DrugMatrix in vitro pharmacology data
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	4.8	pIC50	15951	nM	IC50	DrugMatrix in vitro pharmacology data
ABCB11/Bile salt export pump in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6020] [GtoPdb: 778] [UniProtKB: O95342]
ChEMBL	TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP)	F	4.47	pIC50	33500	nM	IC50	Pharm Res (2003) 20: 537-544 [PMID:12739759]
ChEMBL	TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP)	F	4.51	pIC50	30900	nM	IC50	Pharm Res (2003) 20: 537-544 [PMID:12739759]
Calmodulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6093] [UniProtKB: P0DP23]
ChEMBL	Binding affinity to human calmodulin expressed in Escherichia coli using M124C-mBBr fluorescent biosensor by spectrofluorometer analysis	B	5.91	pKd	1240	nM	Kd	J Nat Prod (2013) 76: 1454-1460 [PMID:23876004]
ChEMBL	Inhibition of recombinant calmodulin mediated bovine brain PDE1 activation assessed as effect on inorganic phosphate release using variable calmodulin level by spectrophotometry	B	4.71	pKi	19280	nM	Ki	Bioorg Med Chem (2009) 17: 2167-2174 [PMID:19013822]
ChEMBL	Inhibition of Calmodulin-dependent PDE1 activity assessed as inorganic phosphate release after 30 min	B	4.99	pIC50	10300	nM	IC50	Eur J Med Chem (2011) 46: 2699-2708 [PMID:21514702]
ChEMBL	Binding affinity to CaM (unknown origin) by equilibrium dialysis method	B	5.1	pIC50	8000	nM	IC50	Eur J Med Chem (2016) 116: 36-45 [PMID:27043269]
ChEMBL	Inhibition of recombinant calmodulin mediated bovine brain PDE1 activation assessed as effect on inorganic phosphate release by spectrophotometry	B	5.14	pIC50	7260	nM	IC50	Bioorg Med Chem (2009) 17: 2167-2174 [PMID:19013822]
Calmodulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6092] [UniProtKB: P62157]
ChEMBL	Binding affinity to bovine brain CaM by FTPFACE analysis	B	5.51	pKd	3100	nM	Kd	Eur J Med Chem (2016) 116: 36-45 [PMID:27043269]
ChEMBL	Displacement of [3H]W-7 from bovine brain CaM	B	5.6	pIC50	2500	nM	IC50	Eur J Med Chem (2016) 116: 36-45 [PMID:27043269]
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)	B	5.13	pKi	7365	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole)	B	4.68	pIC50	20894	nM	IC50	DrugMatrix in vitro pharmacology data
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	6.95	pKi	112	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	B	7.02	pKi	96	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
GtoPdb	-	-	7.1	pKi	-	-	-	Nature (1991) 350: 614-9 [PMID:1826762]
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	6.65	pIC50	225	nM	IC50	DrugMatrix in vitro pharmacology data
D1 receptor/Dopamine D1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL265] [GtoPdb: 214] [UniProtKB: P18901]
ChEMBL	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	B	7.3	pKi	50	nM	Ki	J Med Chem (1988) 31: 1941-1946 [PMID:3050089]
ChEMBL	Binding affinity against dopamine receptor D1	B	7.45	pKi	35.48	nM	Ki	J Med Chem (1994) 37: 519-525 [PMID:7907148]
ChEMBL	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	B	7.46	pKi	35	nM	Ki	J Med Chem (1993) 36: 2107-2114 [PMID:8101877]
ChEMBL	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	B	8.67	pIC50	2.15	nM	IC50	J Med Chem (1995) 38: 318-327 [PMID:7830274]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
GtoPdb	-	-	7.6	pKi	-	-	-	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163]
ChEMBL	DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)	B	7.74	pKi	18	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]spiperone from human dopamine D2 receptor short form expressed in CHO cells	B	8	pKi	10	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	Displacement of [3H]spiperone from dopamine D2-like receptor in porcine striata homogenate	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 6848-6857 [PMID:17154515]
ChEMBL	Displacement of [3H]spiperone from human D2 receptor transfected in HEK cells	B	8.21	pKi	6.1	nM	Ki	J Med Chem (2014) 57: 4368-4381 [PMID:24779610]
ChEMBL	Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells	B	8.39	pKi	4.06	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
ChEMBL	Displacement of [3H]-methylspiperone from human D2 receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method	B	8.63	pKi	2.34	nM	Ki	J Med Chem (2021) 64: 12603-12629 [PMID:34436892]
ChEMBL	Displacement of [3H]-raclopride from human D2 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method	B	8.74	pKi	1.8	nM	Ki	Eur J Med Chem (2019) 180: 383-397 [PMID:31325785]
ChEMBL	Displacement of [3H]-raclopride from recombinant human D2 receptor expressed in HEK293 cells measured after 1 hr by microbeta scintillation counting analysis	B	8.74	pKi	1.8	nM	Ki	Eur J Med Chem (2019) 166: 144-158 [PMID:30703658]
ChEMBL	Displacement of [3H]-N-methylspiperone from human dopamine D2long receptor expressed in HEK293 cells after 30 mins by scintillation counting	B	8.92	pKi	1.2	nM	Ki	Bioorg Med Chem (2012) 20: 6366-6374 [PMID:23018094]
ChEMBL	DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)	B	7.27	pIC50	54	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity to dopamine D2 receptor (unknown origin) by radioligand binding assay	B	7.92	pIC50	12	nM	IC50	J Med Chem (2013) 56: 8955-8971 [PMID:23919353]
ChEMBL	Antagonist activity at human D2 receptor expressed in CHO-K1 cells co-expressing Galphaqi5 assessed as decrease in apomorphine-induced calcium mobilization preincubated for 30 mins followed by apomorphine challenge measured for 30 secs by aequorin-derived luminescence assay	F	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2018) 28: 2039-2049 [PMID:29730027]
ChEMBL	Antagonist activity against human recombinant dopmaine D2L receptor expressed in CHOK1 cells assessed as reduction in apomorphine-induced increase in intracellular Ca2+ levels by aequorin based radiometric and luminescence plate counting method	F	9	pIC50	1	nM	IC50	Eur J Med Chem (2015) 92: 221-235 [PMID:25557493]
ChEMBL	Antagonist activity at human dopamine D2 receptor expressed in CHOK1 cells assessed as inhibition of apomorphine-induced calcium mobilization by radiometric and luminescence plate counting method	F	9	pIC50	1	nM	IC50	Eur J Med Chem (2015) 92: 221-235 [PMID:25557493]
Dopamine D2 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3998] [UniProtKB: P20288]
ChEMBL	Competition in vitro with the dopamine receptor D2 antagonist [3H]spiperone, for binding sites on calf caudate membranes.	B	7.1	pIC50	80	nM	IC50	J Med Chem (1993) 36: 912-918 [PMID:8096548]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL	Tested for Competitive binding inhibition of [3H]spiperone to Dopamine receptor D2 in rat striatal membrane.	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (1993) 3: 1241-1244
GtoPdb	-	-	7.5	pKi	-	-	-	Nature (1990) 347: 146-51 [PMID:1975644]
ChEMBL	In vitro binding affinity for dopamine receptor D2 of rat nucleus accumbens labeled with [3H]spiperone	B	8	pKi	10	nM	Ki	J Med Chem (1987) 30: 1100-1105 [PMID:2884314]
ChEMBL	Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum	B	8.11	pKi	7.8	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]
ChEMBL	Inhibition of [3H]spiperone binding to Dopamine receptor D2 at 0.02 nM	B	8.3	pKi	4.97	nM	Ki	J Med Chem (1988) 31: 1941-1946 [PMID:3050089]
ChEMBL	Compound was evaluated for the binding affinity against [3H]U-86,170-labeled dopamine receptor D2 in cloned CHO cells	B	8.52	pKi	3	nM	Ki	J Med Chem (1993) 36: 1053-1068 [PMID:8097537]
ChEMBL	Compound was evaluated for binding affinity towards Dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the presence of sodium chloride	B	8.66	pKi	2.19	nM	Ki	J Med Chem (1991) 34: 1612-1624 [PMID:1827843]
ChEMBL	In vitro binding affinity against Dopamine D2 receptor in rat striatal tissue.	B	8.7	pKi	2.01	nM	Ki	J Med Chem (1993) 36: 2107-2114 [PMID:8101877]
ChEMBL	Binding affinity against dopamine D2 receptor	B	8.7	pKi	2	nM	Ki	J Med Chem (1994) 37: 519-525 [PMID:7907148]
ChEMBL	Compound was evaluated for binding affinity towards Dopamine receptor D2 in striatal membranes, using [3H]- spiperone as radioligand in the absence of sodium chloride	B	8.75	pKi	1.77	nM	Ki	J Med Chem (1991) 34: 1612-1624 [PMID:1827843]
ChEMBL	Compound was tested for inhibitory activity against the binding of [3H]spiperone to Dopamine receptor D2 in rat striatal membranes	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1987) 30: 1631-1635 [PMID:2887659]
ChEMBL	Compound was tested in vitro for its affinity towards rat striatal Dopamine receptor D2 labeled with [3H]- spiperone	B	7.4	pIC50	40	nM	IC50	J Med Chem (1986) 29: 359-369 [PMID:2869146]
ChEMBL	Ability to bind at dopamine receptor D2 of rat corpus striatum by displacing [3H]spiperone	B	7.4	pIC50	40	nM	IC50	J Med Chem (1989) 32: 1147-1156 [PMID:2542551]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
GtoPdb	-	-	7.5	pKi	-	-	-	J Pharmacol Exp Ther (1994) 268: 417-26 [PMID:8301582]; Eur J Pharmacol (1992) 225: 331-7 [PMID:1354163]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cell membranes by radioligand binding assay	B	7.83	pKi	14.79	nM	Ki	Bioorg Med Chem Lett (2018) 28: 1897-1902 [PMID:29631959]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor by PDSP assay	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2016) 24: 2060-2071 [PMID:27032890]
ChEMBL	Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cell membranes by radioligand binding assay	B	8.12	pKi	7.6	nM	Ki	Bioorg Med Chem Lett (2018) 28: 1897-1902 [PMID:29631959]
ChEMBL	Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells	B	8.16	pKi	6.9	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
ChEMBL	DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)	B	8.38	pKi	4.21	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 30 mins by scintillation counting	B	8.42	pKi	3.8	nM	Ki	Bioorg Med Chem (2012) 20: 6366-6374 [PMID:23018094]
ChEMBL	Displacement of [3H]N-Methylspiperone from dopamine D3 receptor (unknown origin)	B	8.48	pKi	3.31	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]N-Methylspiperone from dopamine D3 receptor (unknown origin)	B	8.48	pKi	3.3	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells	B	8.52	pKi	3	nM	Ki	J Med Chem (2003) 46: 4377-4392 [PMID:14521403]
ChEMBL	Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells	B	8.8	pKi	1.58	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)	B	7.92	pIC50	12	nM	IC50	DrugMatrix in vitro pharmacology data
D3 receptor in Rat [GtoPdb: 216] [UniProtKB: P19020]
GtoPdb	-	-	7.2	pKi	-	-	-	Nature (1990) 347: 146-51 [PMID:1975644]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone)	B	6.32	pKi	479	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]N-Methylspiperone from dopamine D4 receptor (unknown origin)	B	7.5	pKi	31.62	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]N-Methylspiperone from dopamine D4 receptor (unknown origin)	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]spiperone from human dopamine D4.4 receptor expressed in CHO cells	B	7.6	pKi	25.12	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
GtoPdb	-	-	7.8	pKi	-	-	-	Eur J Pharmacol (1993) 236: 483-6 [PMID:8102973]
ChEMBL	DRUGMATRIX: Dopamine D4.2 radioligand binding (ligand: [3H] Spiperone)	B	5.86	pIC50	1365	nM	IC50	DrugMatrix in vitro pharmacology data
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL	Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells	B	6.76	pKi	172	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
GtoPdb	-	-	6.9	pKi	-	-	-	Nature (1991) 350: 614-9 [PMID:1826762]
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.68	pKi	2100	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.58	pIC50	2643	nM	IC50	DrugMatrix in vitro pharmacology data
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr))	B	4.54	pIC50	28868	nM	IC50	DrugMatrix in vitro pharmacology data
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL	Binding affinity against dextromethorpin binding site associated with N-methyl-D-aspartate glutamate receptor from guinea pig mitochondrial pellet P2 determined using [3H]1 as radioligand.	B	5.96	pIC50	1100	nM	IC50	J Med Chem (1992) 35: 4135-4142 [PMID:1433216]
ChEMBL	Inhibition of [3H]1 binding to dextromethorpin binding site of guinea pig microsomal pellet P3 N-methyl-D-aspartate glutamate receptor	B	6.22	pIC50	600	nM	IC50	J Med Chem (1992) 35: 4135-4142 [PMID:1433216]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL	Displacement of [3H]MK-801 from NMDA receptor in Wistar rat brain membranes by scintillation counting analysis	B	4.68	pIC50	21000	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4131-4135 [PMID:26296478]
ChEMBL	Binding affinity against dextromethorpin binding site of N-methyl-D-aspartate glutamate receptor from rat brain using [3H]1	B	5.89	pIC50	1300	nM	IC50	J Med Chem (1992) 35: 4135-4142 [PMID:1433216]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)	B	5.32	pKi	4774.3	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole)	B	5.23	pIC50	5827.5	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human Potassium channel HERG expressed in mammalian cells	B	5.83	pIC50	1479.11	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL	Inhibition of partially open human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel)	F	5.83	pIC50	1479.11	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831]
ChEMBL	Inhibitory concentration against potassium channel HERG	B	5.83	pIC50	1479.11	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL	Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique	B	5.83	pIC50	1479.11	nM	IC50	Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL	Inhibition of human ERG in MCF7 cells	B	5.83	pIC50	1479.11	nM	IC50	Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL	Inhibition of human ERG	B	5.83	pIC50	1479.11	nM	IC50	Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL	Inhibition of hERG K channel	F	5.83	pIC50	1470	nM	IC50	Cardiovasc Res (2011) 91: 53-61 [PMID:21300721]
ChEMBL	K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1	F	5.83	pIC50	1470	nM	IC50	J Med Chem (2002) 45: 3844-3853 [PMID:12190308]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
GtoPdb	-	-	8.2	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]
ChEMBL	Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells	B	8.37	pKi	4.25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
ChEMBL	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	B	8.71	pKi	1.96	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine)	B	7.77	pIC50	17	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity to histamine H1 receptor (unknown origin) by radioligand binding assay	B	7.92	pIC50	12	nM	IC50	J Med Chem (2013) 56: 8955-8971 [PMID:23919353]
Histamine H1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3943] [UniProtKB: P31389]
ChEMBL	Displacement of [3H]pyrilamine from histaminergic H1 receptor guinea pig cerebellum	B	7.3	pKi	50.12	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
H2 receptor/Histamine H2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1941] [GtoPdb: 263] [UniProtKB: P25021]
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	5.59	pKi	2582	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Histamine H2 radioligand binding (ligand: [125I] Aminopotentidine)	B	5.58	pIC50	2626	nM	IC50	DrugMatrix in vitro pharmacology data
H3 receptor/Histamine H3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL264] [GtoPdb: 264] [UniProtKB: Q9Y5N1]
ChEMBL	Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells	B	6	pKi	>1000	nM	Ki	Bioorg Med Chem Lett (2009) 19: 538-542 [PMID:19091563]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	5.35	pKi	4433	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.96	pIC50	11082	nM	IC50	DrugMatrix in vitro pharmacology data
MC3 receptor/Melanocortin receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4644] [GtoPdb: 284] [UniProtKB: P41968]
ChEMBL	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	4.67	pKi	21244	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	4.61	pIC50	24343	nM	IC50	DrugMatrix in vitro pharmacology data
MC4 receptor/Melanocortin receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL259] [GtoPdb: 285] [UniProtKB: P32245]
ChEMBL	DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	4.84	pKi	14619	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	4.82	pIC50	15204	nM	IC50	DrugMatrix in vitro pharmacology data
MC5 receptor/Melanocortin receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4608] [GtoPdb: 286] [UniProtKB: P33032]
ChEMBL	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	5.15	pKi	7145	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH)	B	5.12	pIC50	7617	nM	IC50	DrugMatrix in vitro pharmacology data
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	5.23	pKi	5844	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine)	B	4.84	pIC50	14397	nM	IC50	DrugMatrix in vitro pharmacology data
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Displacement of [3H]pirenzepine from human M1 receptor expressed in CHO cells	B	6.9	pKi	125.89	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.7	pKi	20	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.08	pIC50	83	nM	IC50	DrugMatrix in vitro pharmacology data
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.63	pKi	232	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.19	pIC50	652	nM	IC50	DrugMatrix in vitro pharmacology data
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309]
ChEMBL	DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.36	pKi	44	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.69	pIC50	206	nM	IC50	DrugMatrix in vitro pharmacology data
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173]
ChEMBL	Displacement of [3H]4-DAMP from human M4 receptor expressed in CHO cells	B	6.8	pKi	158.49	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.68	pKi	21	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	6.83	pIC50	149	nM	IC50	DrugMatrix in vitro pharmacology data
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912]
ChEMBL	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.74	pKi	18	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine)	B	7.6	pIC50	25	nM	IC50	DrugMatrix in vitro pharmacology data
NK2 receptor/Neurokinin 2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2327] [GtoPdb: 361] [UniProtKB: P21452]
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	5.04	pKi	9065	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	B	4.57	pIC50	27195	nM	IC50	DrugMatrix in vitro pharmacology data
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	7.72	pKi	19	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	7.72	pIC50	19	nM	IC50	DrugMatrix in vitro pharmacology data
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model	B	4.91	pKi	12200	nM	Ki	J Med Chem (2002) 45: 5671-5686 [PMID:12477351]
ChEMBL	High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model	B	6.22	pKi	600	nM	Ki	J Med Chem (2002) 45: 5671-5686 [PMID:12477351]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.55	pIC50	28000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.52	pIC50	3030	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
Pleiotropic ABC efflux transporter of multiple drugs in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697658] [UniProtKB: P33302]
ChEMBL	Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR5h plasma membrane by spectrofluorometric assay	B	5.35	pIC50	4500	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1516-1527 [PMID:19188399]
K2P2.1/Potassium channel subfamily K member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069]
ChEMBL	Inhibition of of human TREK1 expressed in whole COS cells assessed as reduction in channel currents	B	5.57	pIC50	2700	nM	IC50	J Med Chem (2016) 59: 5149-5157 [PMID:26588045]
Prion protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4869] [UniProtKB: P04156]
ChEMBL	Half maximal inhibition of Prion protein PrPsc formation was assayed in ScN2a cells	B	5.7	pEC50	2000	nM	EC50	J Med Chem (2003) 46: 3563-3564 [PMID:12904059]
Prion protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3698] [UniProtKB: P04925]
ChEMBL	Activity at mouse prion protein expressed in Escherichia coli	B	5.7	pEC50	2000	nM	EC50	J Med Chem (2018) 61: 1276-1284 [PMID:29328660]
erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, ERBB2 (HER2) enzyme inhibition (substrate: Poly(Glu:Tyr))	B	4.71	pIC50	19366	nM	IC50	DrugMatrix in vitro pharmacology data
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4693] [UniProtKB: P04191]
ChEMBL	Inhibition of rabbit skeletal muscle microsomes SERCA1a incubated for 10 mins by enzyme-coupled method	B	4.64	pIC50	23000	nM	IC50	J Med Chem (2020) 63: 1937-1963 [PMID:32030976]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Compound was evaluated for the binding affinity against [3H]8-OH-DPAT-labeled 5-hydroxytryptamine 1A receptor sites in cloned CHO cells	B	6.17	pKi	673	nM	Ki	J Med Chem (1993) 36: 1053-1068 [PMID:8097537]
GtoPdb	-	-	6.2	pKi	-	-	-	Eur J Pharmacol (1998) 355: 245-56 [PMID:9760039]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	5.57	pKi	2677	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	The compound was tested for its binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 radioligand in rat hippocampus	B	6.75	pKi	179	nM	Ki	J Med Chem (1992) 35: 552-558 [PMID:1346653]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT)	B	5.33	pIC50	4685	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Ability to bind at 5-hydroxytryptamine 1A receptor of rat hippocampus by displacing [3H]8-OH-DPAT	B	6.43	pIC50	372	nM	IC50	J Med Chem (1989) 32: 1147-1156 [PMID:2542551]
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)	B	5.74	pKi	1837	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol)	B	5.39	pIC50	4041	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]-ketanserin from human human 5-HT2A receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method	B	7.92	pKi	12.02	nM	Ki	J Med Chem (2021) 64: 12603-12629 [PMID:34436892]
GtoPdb	-	-	8.1	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in CHO cells	B	8.2	pKi	6.31	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin)	B	8.23	pKi	5.9	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin)	B	8.23	pKi	5.89	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)	B	8.96	pKi	1.1	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin)	B	8.41	pIC50	3.85	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity to 5HT2A receptor (unknown origin) by radioligand binding assay	B	8.47	pIC50	3.4	nM	IC50	J Med Chem (2013) 56: 8955-8971 [PMID:23919353]
5-HT2A receptor in Rat [GtoPdb: 6] [UniProtKB: P14842]
GtoPdb	-	-	8.7	pKi	-	-	-	J Pharmacol Exp Ther (1998) 286: 85-90 [PMID:9655845]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	7.1	pKi	80	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	B	7.28	pKi	52	nM	Ki	J Med Chem (2010) 53: 7573-7586 [PMID:20958049]
ChEMBL	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	B	7.4	pKi	39.81	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	6.9	pIC50	126	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Displacement of [3H]mesulergine from 5HT2C receptor expressed in CHO cells	B	7.4	pKi	39.81	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	Displacement of [3H]Mesulergine from 5-HT2C receptor (unknown origin)	B	7.52	pKi	30.2	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]Mesulergine from 5-HT2C receptor (unknown origin)	B	7.52	pKi	30	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]mesulergine from 5-HT2C receptor after 1.5 hrs by scintillation counting	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2011) 19: 5756-5762 [PMID:21907583]
GtoPdb	-	-	8.2	pKi	-	-	-	Neuropsychopharmacology (2003) 28: 519-26 [PMID:12629531]; J Pharmacol Exp Ther (2000) 295: 226-32 [PMID:10991983]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)	B	8.56	pKi	2.74	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine)	B	8.28	pIC50	5.24	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Displacement of [3H]LSD from 5-HT6 receptor (unknown origin)	B	7.22	pKi	60.26	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]LSD from 5-HT6 receptor (unknown origin)	B	7.22	pKi	60	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells	B	7.3	pKi	50.12	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	Binding affinity for human 5-hydroxytryptamine 6 receptor	B	7.3	pKi	<50	nM	Ki	J Med Chem (2005) 48: 1781-1795 [PMID:15771424]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	7.59	pKi	26	nM	Ki	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	7.8	pKi	-	-	-	J Neurochem (1996) 66: 47-56 [PMID:8522988]; Psychopharmacology (Berl.) (2005) 179: 461-9 [PMID:15821958]
ChEMBL	Binding affinity towards human 5-hydroxytryptamine 6 receptor	B	8.4	pKi	4	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)	B	7.24	pIC50	57	nM	IC50	DrugMatrix in vitro pharmacology data
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	8.4	pKi	-	-	-	J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	B	6.92	pKi	120.23	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)	B	6.92	pKi	119	nM	Ki	Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159]
ChEMBL	Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells	B	7.5	pKi	31.62	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	Displacement of [3H]LSD from 5-HT7 receptor after 1.5 hrs by scintillation counting	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem (2011) 19: 5756-5762 [PMID:21907583]
GtoPdb	-	-	7.6	pKi	-	-	-	Psychopharmacology (Berl.) (2005) 179: 461-9 [PMID:15821958]
ChEMBL	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	B	7.96	pKi	11	nM	Ki	Bioorg Med Chem (2013) 21: 2568-2576 [PMID:23541835]
ChEMBL	Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells	B	7.97	pKi	10.72	nM	Ki	Bioorg Med Chem (2013) 21: 2568-2576 [PMID:23541835]
5-HT7 receptor in Mouse [GtoPdb: 12] [UniProtKB: P32304]
GtoPdb	-	-	5.3	pKi	-	-	-	Mol Pharmacol (1993) 44: 229-36 [PMID:8394987]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
GtoPdb	-	-	7.6	pKi	-	-	-	J Pharmacol Exp Ther (1994) 268: 1403-10 [PMID:7908055]
ChEMBL	Binding affinity towards rat 5-hydroxytryptamine 7 receptor	B	7.68	pKi	21	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	Displacement of [3H]paraxetine from human 5HT transporter expressed in HEK293 cells	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2007) 50: 5103-5108 [PMID:17880057]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	7.68	pKi	21	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Binding affinity to SERT (unknown origin) by radioligand binding assay	B	6.92	pIC50	120	nM	IC50	J Med Chem (2013) 56: 8955-8971 [PMID:23919353]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	7.41	pIC50	39	nM	IC50	DrugMatrix in vitro pharmacology data
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)	B	6.72	pKi	189	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol)	B	6.35	pIC50	451	nM	IC50	DrugMatrix in vitro pharmacology data
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy	B	4.57	pIC50	27000	nM	IC50	J Med Chem (2008) 51: 5932-5942 [PMID:18788725]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells	F	5.37	pIC50	4300	nM	IC50	Mol Pharmacol (2003) 63: 489-498 [PMID:12606755]
sphingomyelin phosphodiesterase 1/Sphingomyelin phosphodiesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2760] [GtoPdb: 2514] [UniProtKB: P17405]
ChEMBL	Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method	B	4.96	pIC50	11000	nM	IC50	Eur J Med Chem (2018) 153: 73-104 [PMID:29031494]
Trypanothione reductase in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5131] [UniProtKB: P28593]
ChEMBL	Inhibitory activity against Trypanosoma cruzi trypanothione reductase	B	4.97	pKi	10800	nM	Ki	J Med Chem (2000) 43: 3148-3156 [PMID:10956223]
ChEMBL	Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase (linear competitive type)	B	4.97	pKi	10800	nM	Ki	J Med Chem (1998) 41: 148-156 [PMID:9457238]
ChEMBL	Inhibition of Trypanosoma cruzi recombinant trypanothione reductase	B	5.49	pKi	3200	nM	Ki	Bioorg Med Chem (2008) 16: 6689-6695 [PMID:18558492]
ChEMBL	Inhibitory activity against recombinant Trypanosoma cruzi (Trypanosoma cruzi) Trypanothione reductase	B	4.45	pIC50	35400	nM	IC50	J Med Chem (1998) 41: 148-156 [PMID:9457238]
ChEMBL	Inhibition of Trypanosoma cruzi recombinant trypanothione reductase	B	5.24	pIC50	5800	nM	IC50	Bioorg Med Chem (2008) 16: 6689-6695 [PMID:18558492]
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241]
ChEMBL	DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr))	B	5.06	pIC50	8680	nM	IC50	DrugMatrix in vitro pharmacology data
TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433]
ChEMBL	Displacement of [3H]RTX from rat TRPV1 receptor expressed in CHO cells	B	5.89	pKi	1300	nM	Ki	Bioorg Med Chem (2007) 15: 6043-6053 [PMID:17629487]
ChEMBL	Antagonist activity at rat TRPV1 receptor expressed in CHO cells by Ca2+ uptake assay	F	6.28	pKi	520	nM	Ki	Bioorg Med Chem (2007) 15: 6043-6053 [PMID:17629487]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]