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α1B-adrenoceptor

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Target not currently curated in GtoImmuPdb

Target id: 23

Nomenclature: α1B-adrenoceptor

Family: Adrenoceptors

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 520 5q33.3 ADRA1B adrenoceptor alpha 1B 52
Mouse 7 514 11 25.81 cM Adra1b adrenergic receptor, alpha 1b 36
Rat 7 515 10q21 Adra1b adrenoceptor alpha 1B 2
Previous and Unofficial Names Click here for help
adrenergic alpha 1B receptor | alpha 1B-adrenoceptor | alpha 1B-adrenoreceptor | alpha1B-adrenergic receptor | adrenergic receptor
Database Links Click here for help
Specialist databases
GPCRdb ada1b_human (Hs), ada1b_rat (Mm), ada1b_mouse (Rn)
Other databases
Alphafold P35368 (Hs), P97717 (Mm), P15823 (Rn)
ChEMBL Target CHEMBL232 (Hs), CHEMBL2486 (Mm), CHEMBL315 (Rn)
DrugBank Target P35368 (Hs), P35368 (Hs), P35368 (Hs)
Ensembl Gene ENSG00000170214 (Hs), ENSMUSG00000050541 (Mm), ENSRNOG00000060087 (Rn)
Entrez Gene 147 (Hs), 11548 (Mm), 24173 (Rn)
Human Protein Atlas ENSG00000170214 (Hs)
KEGG Gene hsa:147 (Hs), mmu:11548 (Mm), rno:24173 (Rn)
OMIM 104220 (Hs)
Pharos P35368 (Hs)
RefSeq Nucleotide NM_000679 (Hs), NM_007416 (Mm), NM_016991 (Rn)
RefSeq Protein NP_000670 (Hs), NP_031442 (Mm), NP_058687 (Rn)
UniProtKB P35368 (Hs), P97717 (Mm), P15823 (Rn)
Wikipedia ADRA1B (Hs)
Natural/Endogenous Ligands Click here for help
(-)-adrenaline
(-)-noradrenaline

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
oxymetazoline Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 6.5 pKi 44,59
⤷ pKi 6.5 [44,59]
(-)-adrenaline Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Immunopharmacology Ligand Hs Full agonist 6.5 pKi 59
⤷ pKi 6.5 [59]
(-)-noradrenaline Small molecule or natural product Approved drug Click here for species-specific activity table Ligand is endogenous in the given species Ligand has a PDB structure Hs Full agonist 6.2 pKi 59
⤷ pKi 6.2 [59]
NS-49 Small molecule or natural product Click here for species-specific activity table Hs Partial agonist 5.1 pKi 44
⤷ pKi 5.1 [44]
(+)-adrenaline Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist 5.1 pKi 59
⤷ pKi 5.1 [59]
methoxamine Small molecule or natural product Approved drug Click here for species-specific activity table Hs Full agonist 4.0 pKi 59
⤷ pKi 4.0 [59]
phenylephrine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Full agonist 6.3 – 7.5 pIC50 20,40
⤷ pIC50 6.3 – 7.5 [20,40]
Agonist Comments
Non catecholamine agonists, such as methoxamine and amidephrine, have both low affinity and low intrinsic activity at the α1B- adrenoceptor [40]. Much data has been generated using the hamster α1B-adrenoceptor, since this was the first α1B- homolog to be cloned. There is no evidence for any significant species differences in agonist and antagonist affinity between hamster, rat and human receptors.

Alfuzosin is an approved drug which is an agonist of several α1-adrenoceptors.
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
[125I]HEAT Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Antagonist 10.2 pKd 59
⤷ pKd 10.2 [59]
[125I]BE-2254 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Inverse agonist 9.9 pKd 39,57
⤷ pKd 9.9 [39,57]
(+)-cyclazosin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inverse agonist 9.9 pKi 22
⤷ pKi 9.9 [22]
Rec 15/2615 Small molecule or natural product Hs Antagonist 9.5 pKi 64
⤷ pKi 9.5 [64]
prazosin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inverse agonist 8.7 – 9.9 pKi 20,50,59,70
⤷ pKi 8.7 – 9.9 [20,50,59,70]
NAN 190 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 9.2 pKi 72
⤷ pKi 9.2 [72]
spiperone Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inverse agonist 9.2 pKi 72
⤷ pKi 9.2 [72]
tamsulosin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inverse agonist 8.1 – 9.7 pKi 20,50,59,70
⤷ pKi 8.1 – 9.7 [20,50,59,70]
doxazosin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.5 – 9.1 pKi 27,50
⤷ pKi 8.5 – 9.1 (Ki 8.13x10-10 M) [27,50]
WB 4101 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.5 – 9.0 pKi 20,59
⤷ pKi 8.5 – 9.0 [20,59]
rho-TIA Peptide Hs Antagonist 8.4 pKi 12
⤷ pKi 8.4 [12]
A-119637 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.3 pKi 6
⤷ pKi 8.3 [6]
L-765314 Small molecule or natural product Rn Antagonist 8.3 pKi 47
⤷ pKi 8.3 [47]
terazosin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 8.0 – 8.6 pKi 37,50
⤷ pKi 8.0 – 8.6 [37,50]
clozapine Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 8.2 pKi 72
⤷ pKi 8.2 [72]
ketanserin Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 8.2 pKi 72
⤷ pKi 8.2 [72]
alfuzosin Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 7.6 – 8.6 pKi 28,50
⤷ pKi 7.6 – 8.6 (Ki 2.8x10-9 M) [28,50]
risperidone Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 8.0 pKi 72
⤷ pKi 8.0 [72]
ritanserin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 8.0 pKi 72
⤷ pKi 8.0 [72]
A-123189 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 8.0 pKi 6
⤷ pKi 8.0 [6]
upidosin Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.8 pKi 20
⤷ pKi 7.8 [20]
silodosin Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 7.7 pKi 59
⤷ pKi 7.7 [59]
L-765314 Small molecule or natural product Hs Antagonist 7.7 pKi 47
⤷ pKi 7.7 [47]
spiroxatrine Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.6 pKi 72
⤷ pKi 7.6 [72]
cyproheptadine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs Antagonist 7.6 pKi 72
⤷ pKi 7.6 [72]
AH 11110 Small molecule or natural product Hs Antagonist 7.5 pKi 56
⤷ pKi 7.5 [56]
5-methylurapidil Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.2 – 7.7 pKi 20,59,72
⤷ pKi 7.2 – 7.7 [20,59,72]
mianserin Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 7.4 pKi 72
⤷ pKi 7.4 [72]
indoramin Small molecule or natural product Approved drug Click here for species-specific activity table Hs Antagonist 7.4 pKi 20
⤷ pKi 7.4 [20]
BMY-7378 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.0 – 7.5 pKi 6,72
⤷ pKi 7.0 – 7.5 [6,72]
S(+)-niguldipine Small molecule or natural product Click here for species-specific activity table Hs Antagonist 6.7 – 7.7 pKi 20,59
⤷ pKi 6.7 – 7.7 [20,59]
Ro-70-0004 Small molecule or natural product Click here for species-specific activity table Hs Antagonist 7.1 pKi 70
⤷ pKi 7.1 [70]
phentolamine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Antagonist 6.6 – 7.5 pKi 50,59
⤷ pKi 6.6 – 7.5 [50,59]
KMUP-1 Small molecule or natural product Click here for species-specific activity table Rn Antagonist 6.9 pKi 35
⤷ pKi 6.9 [35]
View species-specific antagonist tables
Antagonist Comments
(+) Cyclazosin shows α1B- selectivity in radioligand binding assays with recombinant receptors; however, a lack of functional selectivity in isolated tissue preparations has been reported [61]. A 19 amino acid peptide, rho-TIA, has been reported to produce non-competitive blockade of α1B-adrenoceptor mediated inositol phosphate formation at concentrations having little effect on this response in cells expressing the other α1 subtypes. Higher concentrations produce nearly complete blockade of the α1B- response, and competitive inhibition of the α1A- and α1D- mediated response [12].
Doxazosin is selective for α1-adrenoceptors.
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
lorazepam Small molecule or natural product Approved drug Rn Positive 3.8 pKi 68
⤷ pKi 3.8 (Ki 1.7x10-4 M) [68]
midazolam Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Rn Positive 3.7 pKi 68
⤷ pKi 3.7 (Ki 1.83x10-4 M) [68]
rho-TIA Peptide Click here for species-specific activity table Rn Negative 9.1 pIC50 34
⤷ pIC50 9.1 (IC50 8x10-10 M) [34]
Allosteric Modulator Comments
ρ-conopeptide TIA is a negative allosteric regulator at the hamster α1B-AR (pKi 7.6, [51]).
Additionally, conopeptide σ-TIA displaces radioligand binding to recombinant α1B-AR in a non-competitive manner [12,25].
Data published by Williams et al. (2018) show that diazepam is not a direct allosteric modulator of α1-adrenoceptors [69], but is able to modulate receptor activity via inhibition of phosphodiesterase 4.
Primary Transduction Mechanisms Click here for help
Transducer Effector/Response
Gq/G11 family Phospholipase C stimulation
Calcium channel
Other - See Comments
Comments:  The α1B-adrenoceptor is coupled to calcium release and inositol phosphate production less efficiently than the α1A but more efficiently than the α1D.
References:  25,39
Secondary Transduction Mechanisms Click here for help
Transducer Effector/Response
Phospholipase D stimulation
Other - See Comments
Comments:  α1- adrenoceptors (all subtypes) can also activate protein Kinase C, mitogen activated protein kinases.
References:  25,39
Tissue Distribution Click here for help
Prostate cancer cell lines DU145, PC3 and TRAMP.
Species:  Human
Technique:  Radioligand binding.
References:  58
Uterus, cervix & umbilical vein.
Species:  Human
Technique:  RT-PCR, tissue contraction.
References:  18-19
Lymphocytes & saphenous vein.
Species:  Human
Technique:  In situ hybridisation.
References:  63,71
Coronary endothelial cells.
Species:  Human
Technique:  PCR, radioligand binding.
References:  30
Osteoblasts & SaM-1 cell line.
Species:  Human
Technique:  RT-PCR, antagonist (chloroethyclonidine) effects.
References:  29,32
α1B-adrenoceptors are either absent or scarce on human prostatic stromal smooth muscle, proximal urethra or corpus cavernosa. α1B-adrenoceptors are found in the human spleen and kidney, and with other subtypes in human somatic arteries and veins.
Species:  Human
Technique:  RT-PCR, RNase protection assay.
References:  39,49
Cerebral cortex, cerebellum, amygdaloid, hypothalamus, midbrain, pontine, spinal cord, olfactory, periaqueductal grey, NG2 oligodendrocytes.
Species:  Mouse
Technique:  In situ hybridisation, GFP-tagged transgenic mouse.
References:  43,45
Testes & spermatocytes.
Species:  Mouse
Technique:  In situ hybridisation.
References:  38
Prefrontal cortex, contralateral hind limb, somatosensory cortex, secondary motor cortex, ipsilateral laminae I-III spinal cord.
Species:  Rat
Technique:  In situ hybridisation.
References:  42,55
High expression levels of α1B-adrenoceptor was found in the medial layer of the aorta and caudal, femoral, iliac, renal, superior mesenteric and mesenteric resistance arteries.
Species:  Rat
Technique:  Immunohistochemistry.
References:  48
Taste buds.
Species:  Rat
Technique:  RT-PCR
References:  78
In the rat brain, highest levels of α1B- adrenoceptor protein are found in regions involved in stress and neuroendocrine function. Intense labeling was found in hypothalamic paraventricular nuclei, supraoptic nucleus, median eminence and arcuate nucleus. Immunoreactivity was also found in layer V of the frontal cortex, thalamus, hippocampus, diagonal band of Broca and caudate-putamen. Some midbrain and hindbrain regions important for motor function were also immunoreactive.
Species:  Rat
Technique:  Immunohistochemistry.
References:  1,14
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays Click here for help
Isolated longitudinal strip of rat spleen.
Species:  Rat
Tissue:  Spleen
Response measured:  Contraction
References:  61
Isolated first order venules.
Species:  Human
Tissue:  Vasculature
Response measured:  Vasculature
References:  23
Nerve growth factor augments neuronal responsiveness to norepinephrine by increasing α1B-AR expression.
Species:  Rat
Tissue:  Primary dorsal root ganglion cells.
Response measured:  Neuronal responsiveness.
References:  77
Sphingosine-1-phosphate or lysophosphatidic acid induced α1B-AR desensitization and phosphorylation through PI3K and PKC and EGFR translocation.
Species:  Rat
Tissue:  Transfected Rat-1 fibroblasts.
Response measured:  Phosphorylation and desensitization.
References:  8-9
During renal impairment, α1B-AR mediated adrenergic-induced renal vasoconstriction but not during normal renal function.
Species:  Rat
Tissue:  Kidney.
Response measured:  Vasconstriction.
References:  31
T130A mutation in transmembrane domain III has reduced binding affinity for prazosin and tamsulosin.
Species:  Human
Tissue:  HEK 293 cells transfected with human α1B-AR cDNA.
Response measured:  Binding affinity.
References:  62
Insulin induces phosphorylation and desensitization; insulin-like growth factor-1 induces α1B-AR desensitization, phosphorylation and internalization through a PTX-sensitive pathway and the EGF receptor. Estrogen also desensitizes α1B-AR through the PI3K and PKC pathways.
Species:  Human
Tissue:  Transfected Rat-1 cells & DDT1MF2 cells.
Response measured:  Desensitization and internalization.
References:  7,21,24,41
α1B- and α1D-ARs form heterodimers with enhanced inositol phosphate release. Also forms heterodimers with α1A-AR. Heterodimer formation is observed for human AND rat receptors.
Species:  Human
Tissue:  Transfected HEK 293 & DDT(1)MF-2 cells.
Response measured:  Heterodimer formation.
References:  26,66
Physiological Functions Click here for help
Contraction of mesenteric resistance arteries.
Species:  Rat
Tissue:  Vasculature.
References:  48
α1B-adrenoceptors appear to be involved in the regulation of cardiac growth and contractile function.
Species:  Mouse
Tissue:  Heart.
References:  11
Contraction of mammary artery and saphenous vein (with α1A).
Species:  Human
Tissue:  Vasculature
References:  23
Adrenaline induced stimulation of hydroxyl radical formation in isolated hepatocytes.
Species:  Rat
Tissue:  Liver.
References:  10
CNS Stimulation by d-amphetamine, cocaine and morphine.
Species:  Mouse
Tissue:  Brain.
References:  17
Growth of vascular adventitia following balloon injury.
Species:  Rat
Tissue:  Aorta.
References:  76
Contraction of umbilical vein.
Species:  Human
Tissue:  Vasculature.
References:  19
α1B-AR activation initiates a PLC-dependent biphasic change in pinealocyte membrane potential.
Species:  Rat
Tissue:  Primary pinealocytes.
References: 
Increased replication of human osteoblasts.
Species:  Human
Tissue:  Bone.
References:  29
Diabetes increases α1B-AR mRNA in non-pregnant rats.
Species:  Rat
Tissue:  Uterus.
References:  60
Physiological Consequences of Altering Gene Expression Click here for help
α1B- knockout mice have elevated glycogen stores in both fed and fasted state and are hyperinsulinemic when fasted. They are more sensitive to obesity induced by a high fat diet.
Species:  Mouse
Tissue: 
Technique:  Transgenesis.
References:  13
Mice with myocyte-targeted α1B-ARs develop spontaneous ventricular arrhythmias and repolarization defects with age
Species:  Mouse
Tissue:  Heart.
Technique:  Gene over-expression.
References:  53
α1B-AR knockout mice display reduced neointimal growth, adventitial thickening and lumen loss. α1B-AR mediates vascular remodeling trophic effects after injury.
Species:  Mouse
Tissue:  Carotid artery.
Technique:  Gene knockout.
References:  75
Mice with constitutively active mutation (CAM) have decreased inotropic response to phenylephrine (decreased cardiac function).
Species:  Mouse
Tissue:  Heart.
Technique:  Gene over-expression, Langendorff isolated perfused heart assay.
References:  54
Mice with constitutively active mutation (CAM) have increased apoptosis, NMDA receptors, but decreased GABA-A receptor (neurodegenerative profile).
Species:  Mouse
Tissue:  Brain.
Technique:  Gene over-expression and microarry analysis.
References:  73
Mice with constitutively active mutation (CAM) have cardiac gene expression profile consistent with maladaptive hypertrophy (a gene expression profile of inflammation, hypertrophy, Src related signaling).
Species:  Mouse
Tissue:  Heart.
Technique:  Gene over-expression and microarray analysis.
References:  74
Mice with constitutively active mutation (CAM) have increased spontaneous interictal epileptogenicity and EEG /behavioral seizures (epilepsy).
Species:  Mouse
Tissue:  Brain.
Technique:  Gene over-expression.
References:  33
Mice with constitutively active mutation (CAM) have progressive synucleinopathy that is rescued by long-term terazosin treatment (abnormal aggregated alpha-synuclein inclusion bodies & Purkinje cell loss).
Species:  Mouse
Tissue:  Brain.
Technique:  Gene over-expression.
References:  46
Mice with constitutively active mutation (CAM) have progressive apoptotic parkinsonian-like neurodegeneration with multiple system atrophy (granulovacular apoptotic neurodegeneration, movement disorder, dopaminergic degeneration).
Species:  Mouse
Tissue:  Heart.
Technique:  Gene over-expression.
References:  80
α1B-AR knockout mice exhibit altered locomoter and rewarding effects of psychostimulants and opiates; mediates dopamine release (hyperactivity and rewarding behavior of cocaine, morphine, amphetamine).
Species:  Mouse
Tissue:  Brain.
Technique:  Gene knockouts.
References:  3,15,67
α1B-AR knockout mice display attenuated pressor and positive inotropic effects after transient bilateral carotid occlusion and denervated aortic baroreceptor surgery. α1B-AR regulates sympathetic neuroeffector junction and baroreceptor activation.
Species:  Mouse
Tissue:  Mesenteric vasculature.
Technique:  Gene knockout.
References:  65
α1B-AR knockout mice display compensatory changes in α1-AR subtypes; liver from α1B-AR knockout animals displays increased α1A-AR expression.
Species:  Mouse
Tissue:  Liver, hepatocytes.
Technique:  Gene knockout.
References:  16
α1B-AR knockout mice display impaired glucose homeostasis (hyperinsulinemia and insulin resistance).
Species:  Mouse
Tissue:  Blood, liver.
Technique:  Gene knockout.
References:  5
Mice with constitutively active mutation (CAM) have hypotension, autonomic failure and cardiac hypertrophy (lower basal and phenylephrine-induced blood pressure, cardiac hypertrophy, cardiac dysfunction, reduced plasma catecholamines and cortisol, weight loss).
Species:  Mouse
Tissue:  Brain & heart.
Technique:  Gene over-expression.
References:  79
α1B-AR knockout mice display reduced fertility and spermatogenesis (hypofertile, low testosterone, high leutinizing hormone).
Species:  Mouse
Tissue:  Testes.
Technique:  Gene knockouts.
References:  38
α1B-AR knockout mice are protected against methamphetamine induced degeneration (methamphetamine toxicity) of the nigro-striatal neuronal pathway in CNS and show an enhanced reactivity to new situations.
Species:  Mouse
Tissue:  Brain- nigro-striatal projection.
Technique:  Gene knockout.
References:  4
Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0004184 abnormal baroreceptor physiology PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002972 abnormal cardiac muscle contractility PMID: 14519431 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0000304 abnormal cardiac stroke volume PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0001544 abnormal cardiovascular system physiology PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002332 abnormal exercise endurance PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002078 abnormal glucose homeostasis PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0003921 abnormal heart left ventricle morphology PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005406 abnormal heart size PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001449 abnormal learning/ memory PMID: 11222061 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004215 abnormal myocardial fiber physiology PMID: 14519431 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0003562 abnormal pancreatic beta cell physiology PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0003461 abnormal response to novel object PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002216 abnormal seminiferous tubule morphology PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002784 abnormal Sertoli cell morphology PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001463 abnormal spatial learning PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0000230 abnormal systemic arterial blood pressure PMID: 9326654 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002782 abnormal testicular secretion PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001155 arrest of spermatogenesis PMID: 17951539 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0006138 congestive heart failure PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0005140 decreased cardiac muscle contractility PMID: 15466664  9326654 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003393 decreased cardiac output PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002702 decreased circulating free fatty acid level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0002780 decreased circulating testosterone level PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0001417 decreased exploration in new environment PMID: 11115730 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005439 decreased glycogen level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0005333 decreased heart rate PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005333 decreased heart rate PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002834 decreased heart weight PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001935 decreased litter size PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0004901 decreased male germ cell number PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0002843 decreased systemic arterial blood pressure PMID: 15466664 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0006264 decreased systemic arterial systolic blood pressure PMID: 15466664 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0004852 decreased testis weight PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0003026 decreased vasoconstriction PMID: 15466664 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003068 enlarged kidney PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001559 hyperglycemia PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0009750 impaired behavioral response to addictive substance PMID: 11923452 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0009712 impaired conditioned place preference behavior PMID: 11923452 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005293 impaired glucose tolerance PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd		 MGI:104774  MP:0004000 impaired passive avoidance behavior PMID: 11115730 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0005599 increased cardiac muscle contractility PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0002079 increased circulating insulin level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005669 increased circulating leptin level PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001751 increased circulating luteinizing hormone level PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0001415 increased exploration in new environment PMID: 11222061 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005440 increased glycogen level PMID: 14581480 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0003823 increased left ventricular developed pressure PMID: 14519431 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005458 increased percent body fat PMID: 14581480 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004485 increased response of heart to induced stress PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0009763 increased sensitivity to induced morbidity/mortality PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005658 increased susceptibility to diet-induced obesity PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * C57BL/6J		 MGI:104774  MP:0005331 insulin resistance PMID: 14581480 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0008280 male germ cell apoptosis PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001925 male infertility PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001922 reduced male fertility PMID: 17951539 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0002188 small heart PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
B6.129-Adra1b Adra1a		 MGI:104773  MGI:104774  MP:0002188 small heart PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N		 MGI:104773  MGI:104774  MP:0004565 small myocardial fiber PMID: 12782680 
Adra1atm1Pcs|Adra1btm1Cta Adra1atm1Pcs/Adra1atm1Pcs,Adra1btm1Cta/Adra1btm1Cta
B6.129-Adra1b Adra1a		 MGI:104773  MGI:104774  MP:0004565 small myocardial fiber PMID: 12782680 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001157 small seminal vesicle PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001153 small seminiferous tubules PMID: 17951539 
Adra1btm1Cta Adra1btm1Cta/Adra1btm1Cta
involves: 129/Sv * C57BL/6J		 MGI:104774  MP:0001147 small testis PMID: 17951539 

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