A-769662 [Ligand Id: 10069] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL512504 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| K2P9.1 in Human [GtoPdb: 520] [UniProtKB: Q9NPC2] | ||||||||
| GtoPdb | - | - | 3.52 | pIC50 | 300000 | nM | IC50 | Biochem Pharmacol (2024) 230: 116562 [PMID:39362502] |
| AMP kinase in Human [GtoPdb: 1540] | ||||||||
| GtoPdb | Activation of AMPK partially purified from HEK cells. | - | 5.96 | pEC50 | 1100 | nM | EC50 | Cell Metab (2006) 3: 403-16 [PMID:16753576] |
| AMP kinase in Rat [GtoPdb: 1540] | ||||||||
| GtoPdb | Activation of baculovirus expressed α1,β1,&gamma1 recombinant isoform of AMPK. | - | 6.15 | pEC50 | 700 | nM | EC50 | Cell Metab (2006) 3: 403-16 [PMID:16753576] |
| GtoPdb | Activation of AMPK purified from rat liver, which contains α1 and α2 catalytic subunits, with β1 and γ1 regulatory subunits. | - | 6.94 | pEC50 | 116 | nM | EC50 | J Biol Chem (2007) 282: 32549-60 [PMID:17855357] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
